U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    QRSL1 glutaminyl-tRNA amidotransferase subunit QRSL1 [ Homo sapiens (human) ]

    Gene ID: 55278, updated on 6-Jun-2024

    Summary

    Official Symbol
    QRSL1provided by HGNC
    Official Full Name
    glutaminyl-tRNA amidotransferase subunit QRSL1provided by HGNC
    Primary source
    HGNC:HGNC:21020
    See related
    Ensembl:ENSG00000130348 MIM:617209; AllianceGenome:HGNC:21020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GatA; COXPD40
    Summary
    Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 7.2), thyroid (RPKM 5.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See QRSL1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (106629578..106668417)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (107806065..107844870)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (107077453..107116292)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene uncharacterized LOC101927405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:106957727-106958332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:106959060-106960018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17433 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:106967140-106968339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:107023180-107023700 Neighboring gene MPRA-validated peak6003 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr6:107033226-107033920 Neighboring gene reticulon 4 interacting protein 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:107061294-107061801 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:107062309-107062815 Neighboring gene RNA, U6 small nuclear 527, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24893 Neighboring gene ribosomal protein L21 pseudogene 65 Neighboring gene uncharacterized LOC105377927 Neighboring gene long intergenic non-protein coding RNA 2526

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10989, FLJ12189, FLJ13447, DKFZp564C1278

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of glutamyl-tRNA(Gln) amidotransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Names
    QRSL1, glutaminyl-tRNA amidotransferase subunit A
    glu-AdT subunit A
    glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
    glutaminyl-tRNA synthase-like protein 1
    glutamyl-tRNA(Gln) amidotransferase subunit A homolog
    glutamyl-tRNA(Gln) amidotransferase, subunit A
    NP_060762.3
    XP_011534226.1
    XP_054211756.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018292.5NP_060762.3  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

      See identical proteins and their annotated locations for NP_060762.3

      Status: VALIDATED

      Source sequence(s)
      AL390074, BC014389, DA819470
      Consensus CDS
      CCDS5057.1
      UniProtKB/Swiss-Prot
      Q5VWJ4, Q9H0R6, Q9HA60, Q9NV19
      UniProtKB/TrEMBL
      B2RBJ8
      Related
      ENSP00000358042.4, ENST00000369046.8
      Conserved Domains (1) summary
      PRK00012
      Location:13495
      gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      106629578..106668417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535924.3XP_011534226.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011534226.1

      UniProtKB/TrEMBL
      B2RBJ8
      Conserved Domains (1) summary
      PRK00012
      Location:1404
      gatA; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      107806065..107844870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355781.1XP_054211756.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2RBJ8