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    THNSL2 threonine synthase like 2 [ Homo sapiens (human) ]

    Gene ID: 55258, updated on 17-Jun-2019

    Summary

    Official Symbol
    THNSL2provided by HGNC
    Official Full Name
    threonine synthase like 2provided by HGNC
    Primary source
    HGNC:HGNC:25602
    See related
    Ensembl:ENSG00000144115 MIM:611261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THS2; TSH2; SOFAT
    Summary
    This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 9.9), thyroid (RPKM 9.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See THNSL2 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (88170295..88186637)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88469814..88486156)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 1 Neighboring gene microRNA 4780 Neighboring gene uncharacterized LOC101928347 Neighboring gene fatty acid binding protein 1 Neighboring gene RNY4 pseudogene 15 Neighboring gene mitochondrial ribosomal protein L45 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of threonine synthase-like 2 (THNSL2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10916, FLJ35504

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pyridoxal phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    serine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    threonine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT threonine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    2-oxobutyrate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    2-oxobutyrate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    serine family amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine family amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    threonine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT threonine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    threonine synthase-like 2
    Names
    secreted osteoclastogenic factor of activated T cells
    NP_001231605.1
    NP_001231607.1
    NP_060741.3
    XP_005264457.1
    XP_005264458.1
    XP_005264459.1
    XP_005264460.1
    XP_005264462.1
    XP_006712104.1
    XP_006712105.1
    XP_006712106.1
    XP_006712107.1
    XP_011531255.1
    XP_011531256.1
    XP_011531257.1
    XP_024308743.1
    XP_024308744.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030037.1 RefSeqGene

      Range
      5001..21343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244676.1NP_001231605.1  threonine synthase-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001231605.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a longer 5' UTR and uses an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC092836, AI313402, BC064423, BI765911
      Consensus CDS
      CCDS58718.1
      UniProtKB/Swiss-Prot
      Q86YJ6
      Related
      ENSP00000339563.4, ENST00000343544.8
      Conserved Domains (1) summary
      cd01560
      Location:2359
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    2. NM_001244678.1NP_001231607.1  threonine synthase-like 2 isoform 3

      See identical proteins and their annotated locations for NP_001231607.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC092836, AI313402, AK315831, BI765911
      Consensus CDS
      CCDS74539.1
      UniProtKB/TrEMBL
      A8K0C1
      Related
      ENSP00000366464.4, ENST00000377254.7
      Conserved Domains (1) summary
      cl00342
      Location:1201
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    3. NM_018271.4NP_060741.3  threonine synthase-like 2 isoform 1

      See identical proteins and their annotated locations for NP_060741.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092836, AI313402, BC035315, DA196694
      Consensus CDS
      CCDS2002.2
      UniProtKB/Swiss-Prot
      Q86YJ6
      Related
      ENSP00000327323.5, ENST00000324166.6
      Conserved Domains (1) summary
      cd01560
      Location:2464
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      88170295..88186637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264400.4XP_005264457.1  threonine synthase-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005264457.1

      UniProtKB/Swiss-Prot
      Q86YJ6
      Conserved Domains (1) summary
      cd01560
      Location:2464
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    2. XM_024452975.1XP_024308743.1  threonine synthase-like 2 isoform X1

      Conserved Domains (1) summary
      cd01560
      Location:2464
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    3. XM_011532955.2XP_011531257.1  threonine synthase-like 2 isoform X10

      Conserved Domains (1) summary
      cl00342
      Location:1306
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    4. XM_024452976.1XP_024308744.1  threonine synthase-like 2 isoform X12

    5. XM_005264401.5XP_005264458.1  threonine synthase-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005264458.1

      UniProtKB/Swiss-Prot
      Q86YJ6
      Conserved Domains (1) summary
      cd01560
      Location:2464
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    6. XM_006712041.3XP_006712104.1  threonine synthase-like 2 isoform X3

      Conserved Domains (2) summary
      cd01560
      Location:2408
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1397
      PRK09225; threonine synthase; Validated
    7. XM_005264403.4XP_005264460.1  threonine synthase-like 2 isoform X8

      UniProtKB/Swiss-Prot
      Q86YJ6
      Conserved Domains (1) summary
      cd01560
      Location:2359
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    8. XM_005264405.4XP_005264462.1  threonine synthase-like 2 isoform X9

      Conserved Domains (1) summary
      cd01560
      Location:2359
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    9. XM_006712044.3XP_006712107.1  threonine synthase-like 2 isoform X11

      Related
      ENSP00000407553.1, ENST00000449349.5
      Conserved Domains (1) summary
      cl00342
      Location:2268
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    10. XM_011532954.2XP_011531256.1  threonine synthase-like 2 isoform X6

      Conserved Domains (2) summary
      cd01560
      Location:2399
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1389
      PRK09225; threonine synthase; Validated
    11. XM_006712043.2XP_006712106.1  threonine synthase-like 2 isoform X7

      See identical proteins and their annotated locations for XP_006712106.1

      UniProtKB/Swiss-Prot
      Q86YJ6
      Conserved Domains (1) summary
      cd01560
      Location:2359
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    12. XM_011532953.2XP_011531255.1  threonine synthase-like 2 isoform X2

      Conserved Domains (2) summary
      cd01560
      Location:2408
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1397
      PRK09225; threonine synthase; Validated
    13. XM_005264402.3XP_005264459.1  threonine synthase-like 2 isoform X4

      Conserved Domains (2) summary
      cd01560
      Location:2408
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1397
      PRK09225; threonine synthase; Validated
    14. XM_006712042.3XP_006712105.1  threonine synthase-like 2 isoform X5

      Conserved Domains (2) summary
      cd01560
      Location:2408
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1397
      PRK09225; threonine synthase; Validated

    RNA

    1. XR_002959311.1 RNA Sequence

    2. XR_001738821.1 RNA Sequence

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