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    OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55239, updated on 30-Jun-2019

    Summary

    Official Symbol
    OGFOD1provided by HGNC
    Official Full Name
    2-oxoglutarate and iron dependent oxygenase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25585
    See related
    Ensembl:ENSG00000087263 MIM:615857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPA1
    Expression
    Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See OGFOD1 in Genome Data Viewer
    Location:
    16q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56451524..56479104)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56485424..56511407)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene autocrine motility factor receptor Neighboring gene nudix hydrolase 21 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene uncharacterized LOC105371283 Neighboring gene metallothionein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10826, KIAA1612

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-proline 3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-proline dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-proline dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-proline hydroxylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-proline hydroxylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein hydroxylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of translational termination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic stress granule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    prolyl 3-hydroxylase OGFOD1
    Names
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
    TPA1, termination and polyadenylation 1, homolog
    termination and polyadenylation 1 homolog
    uS12 prolyl 3-hydroxylase
    NP_001311286.1
    NP_001311287.1
    NP_001311288.1
    NP_001311289.1
    NP_001311290.1
    NP_001311291.1
    NP_001311292.1
    NP_060703.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324357.2NP_001311286.1  prolyl 3-hydroxylase OGFOD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092140
    2. NM_001324358.1NP_001311287.1  prolyl 3-hydroxylase OGFOD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092140
    3. NM_001324359.1NP_001311288.1  prolyl 3-hydroxylase OGFOD1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC092140
    4. NM_001324360.2NP_001311289.1  prolyl 3-hydroxylase OGFOD1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC092140
    5. NM_001324361.1NP_001311290.1  prolyl 3-hydroxylase OGFOD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092140
    6. NM_001324362.1NP_001311291.1  prolyl 3-hydroxylase OGFOD1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC092140
      UniProtKB/Swiss-Prot
      Q8N543
      Conserved Domains (1) summary
      cl21496
      Location:122398
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    7. NM_001324363.2NP_001311292.1  prolyl 3-hydroxylase OGFOD1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC092140
    8. NM_018233.4NP_060703.3  prolyl 3-hydroxylase OGFOD1 isoform 1

      See identical proteins and their annotated locations for NP_060703.3

      Status: VALIDATED

      Source sequence(s)
      AC092140, BC032919
      Consensus CDS
      CCDS10761.2
      UniProtKB/Swiss-Prot
      Q8N543
      Related
      ENSP00000457258.1, ENST00000566157.5
      Conserved Domains (2) summary
      smart00702
      Location:72238
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      cl21496
      Location:262538
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      56451524..56479104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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