U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NKAPD1 NKAP domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55216, updated on 5-Feb-2023

    Summary

    Official Symbol
    NKAPD1provided by HGNC
    Official Full Name
    NKAP domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25569
    See related
    Ensembl:ENSG00000150776 AllianceGenome:HGNC:25569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf57
    Summary
    Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.5), brain (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NKAPD1 in Genome Data Viewer
    Location:
    11q23.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (112074299..112085150)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (112084552..112095404)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111945023..111955874)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 893, pseudogene Neighboring gene dihydrolipoamide S-acetyltransferase Neighboring gene PIH1 domain containing 2 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene interleukin 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10726

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    uncharacterized protein NKAPD1
    Names
    NKAP domain containing protein 1
    uncharacterized protein C11orf57

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082969.2NP_001076438.1  uncharacterized protein NKAPD1 isoform a

      See identical proteins and their annotated locations for NP_001076438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AB096251, BM670479, CD706604
      Consensus CDS
      CCDS8356.2
      UniProtKB/TrEMBL
      A0A024R3H5
      Conserved Domains (1) summary
      pfam15692
      Location:86147
      NKAP; NF-kappa-B-activating protein
    2. NM_001082970.2NP_001076439.1  uncharacterized protein NKAPD1 isoform b

      See identical proteins and their annotated locations for NP_001076439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal aa, compared to isoform a.
      Source sequence(s)
      AK125340, AP002007, BM670479, EL736728
      Consensus CDS
      CCDS41715.1
      UniProtKB/Swiss-Prot
      Q6ZUT1, Q8N2T3
      Related
      ENSP00000339076.7, ENST00000280352.13
      Conserved Domains (1) summary
      pfam15692
      Location:86146
      NKAP; NF-kappa-B-activating protein
    3. NM_001301017.2NP_001287946.1  uncharacterized protein NKAPD1 isoform b

      See identical proteins and their annotated locations for NP_001287946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
      Source sequence(s)
      AP002007, BC072455, BX538107, CD706604
      Consensus CDS
      CCDS41715.1
      UniProtKB/Swiss-Prot
      Q6ZUT1, Q8N2T3
      Related
      ENSP00000402208.2, ENST00000420986.6
      Conserved Domains (1) summary
      pfam15692
      Location:86146
      NKAP; NF-kappa-B-activating protein
    4. NM_001301019.2NP_001287948.1  uncharacterized protein NKAPD1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction at the 3' end of an exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AP002007, BX538107, CD244552, CD706604
      Consensus CDS
      CCDS73383.1
      UniProtKB/Swiss-Prot
      Q6ZUT1
      Related
      ENSP00000435408.1, ENST00000525785.5
      Conserved Domains (1) summary
      pfam15692
      Location:57118
      NKAP; NF-kappa-B-activating protein
    5. NM_001301021.2NP_001287950.1  uncharacterized protein NKAPD1 isoform d

      See identical proteins and their annotated locations for NP_001287950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice junction at the 3' end of an exon and an alternate in-frame exon at the 5' end of the last exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks a single internal aa compared to isoform a.
      Source sequence(s)
      AP002007, BX538107, DA813095
      UniProtKB/Swiss-Prot
      Q6ZUT1
      Conserved Domains (1) summary
      pfam15692
      Location:56117
      NKAP; NF-kappa-B-activating protein
    6. NM_018195.4NP_060665.3  uncharacterized protein NKAPD1 isoform a

      See identical proteins and their annotated locations for NP_060665.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 both encode the same isoform (a).
      Source sequence(s)
      AP002007, BG115155, BM670479, CD706604, DT220380
      Consensus CDS
      CCDS8356.2
      UniProtKB/TrEMBL
      A0A024R3H5
      Related
      ENSP00000376767.3, ENST00000393047.8
      Conserved Domains (1) summary
      pfam15692
      Location:86147
      NKAP; NF-kappa-B-activating protein

    RNA

    1. NR_103469.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB096251, BX538107, CD244552

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      112074299..112085150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427197.1XP_047283153.1  uncharacterized protein NKAPD1 isoform X1

      UniProtKB/TrEMBL
      A0A024R3H5
    2. XM_047427198.1XP_047283154.1  uncharacterized protein NKAPD1 isoform X2

      UniProtKB/Swiss-Prot
      Q8N2T3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      112084552..112095404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)