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    INTS10 integrator complex subunit 10 [ Homo sapiens (human) ]

    Gene ID: 55174, updated on 17-Jun-2019

    Summary

    Official Symbol
    INTS10provided by HGNC
    Official Full Name
    integrator complex subunit 10provided by HGNC
    Primary source
    HGNC:HGNC:25548
    See related
    Ensembl:ENSG00000104613 MIM:611353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT10; C8orf35
    Summary
    INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See INTS10 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (19817149..19852083)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19674876..19709589)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene uncharacterized LOC105379308 Neighboring gene uncharacterized LOC107986920 Neighboring gene uncharacterized LOC105379309 Neighboring gene uncharacterized LOC107986921

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
    NHGRI GWA Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
      RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    snRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    snRNA transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integrator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrator complex subunit 10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353505.1NP_001340434.1  integrator complex subunit 10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC107964
    2. NM_001353506.1NP_001340435.1  integrator complex subunit 10 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC107964
    3. NM_001353507.1NP_001340436.1  integrator complex subunit 10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC107964
    4. NM_001353508.1NP_001340437.1  integrator complex subunit 10 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC107964
    5. NM_001353509.1NP_001340438.1  integrator complex subunit 10 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC107964
    6. NM_001353510.1NP_001340439.1  integrator complex subunit 10 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC107964
    7. NM_001353511.1NP_001340440.1  integrator complex subunit 10 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC107964
    8. NM_001353512.1NP_001340441.1  integrator complex subunit 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC107964
    9. NM_001353513.1NP_001340442.1  integrator complex subunit 10 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC107964
    10. NM_001353514.1NP_001340443.1  integrator complex subunit 10 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC107964
    11. NM_001353515.1NP_001340444.1  integrator complex subunit 10 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC107964
    12. NM_001353516.1NP_001340445.1  integrator complex subunit 10 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC107964
    13. NM_001353517.1NP_001340446.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), along with variants 15 and 16, encodes isoform n.
      Source sequence(s)
      AC107964
    14. NM_001353518.1NP_001340447.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), along with variants 14 and 16, encodes isoform n.
      Source sequence(s)
      AC107964
    15. NM_001353519.1NP_001340448.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), along with variants 14 and 15, encodes isoform n.
      Source sequence(s)
      AC107964
    16. NM_001353520.1NP_001340449.1  integrator complex subunit 10 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC107964
    17. NM_001353521.1NP_001340450.1  integrator complex subunit 10 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform p.
      Source sequence(s)
      AC107964
    18. NM_001353522.1NP_001340451.1  integrator complex subunit 10 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform p.
      Source sequence(s)
      AC107964
    19. NM_018142.4NP_060612.2  integrator complex subunit 10 isoform g

      See identical proteins and their annotated locations for NP_060612.2

      Status: VALIDATED

      Source sequence(s)
      AC107964
      Consensus CDS
      CCDS6011.2
      UniProtKB/Swiss-Prot
      Q9NVR2
      Related
      ENSP00000381064.3, ENST00000397977.8

    RNA

    1. NR_148451.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    2. NR_148452.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    3. NR_148453.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    4. NR_148454.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    5. NR_148455.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    6. NR_148456.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    7. NR_148457.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964
    8. NR_148458.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      19817149..19852083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013607.1XP_016869096.1  integrator complex subunit 10 isoform X2

    2. XM_017013606.2XP_016869095.1  integrator complex subunit 10 isoform X1

    RNA

    1. XR_001745550.2 RNA Sequence

    2. XR_002956637.1 RNA Sequence

    3. XR_001745551.2 RNA Sequence

    4. XR_001745552.2 RNA Sequence

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