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    PRMT6 protein arginine methyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 55170, updated on 21-Apr-2019

    Summary

    Official Symbol
    PRMT6provided by HGNC
    Official Full Name
    protein arginine methyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:18241
    See related
    Ensembl:ENSG00000198890 MIM:608274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRMT1L6
    Summary
    The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
    Orthologs

    Genomic context

    See PRMT6 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (107056645..107059294)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107599267..107601916)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene nudE neurodevelopment protein 1 pseudogene 1 Neighboring gene netrin G1 Neighboring gene NDUFA4 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    NHGRI GWA Catalog
    A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
    NHGRI GWA Catalog
    Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
    NHGRI GWA Catalog
    Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
    NHGRI GWA Catalog
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env (gp160) protein methylation mediated by PRMT6 is required to maintain optimal HIV-1 infectivity PubMed
    Rev rev PRMT6 mutant V86K/D88A fails to methylate HIV-1 Rev. PRMT6 is automethylated at position R35, which regulates its stability and is necessary for its HIV-1 restriction activity PubMed
    rev Arginine 38 methylation of HIV-1 Rev by PRMT6 reduces RRE binding and diminishes export of viral RNA to the cytoplasm PubMed
    Tat tat HIV-1 Tat nucleolar retention (dependent on Tat residues 49-57) is inhibited by PRMT6 PubMed
    tat The termini (residues 1-84 and 321-375) of PRMT6 and the activation domain (residues 1-37) of HIV-1 Tat are required for the interaction between PRMT6 and Tat PubMed
    tat PRMT6 increases the steady-state level of HIV-1 Tat in the cell and the basic domain (residues 49-57) of Tat is required for the PRMT6-mediated increase of Tat steady-state levels PubMed
    tat HIV-1 Tat is methylated at positions Arg52 and Arg53 by PRMT6. Arginine methylation of Tat negatively affects Tat-TAR-cyclin T1 ternary complex formation and diminishes cyclin T1-dependent Tat transcriptional activation PubMed
    tat HIV-1 Tat specifically interacts with and is methylated by PRMT6 within cells; overexpression of wild-type PRMT6 decreases Tat transactivation of an HIV-1 long terminal repeat luciferase reporter plasmid in a dose-dependent manner PubMed
    nucleocapsid gag HIV-1 NC is methylated at positions Arg10 and Arg32 by PRMT6 both in vitro and in vivo, and methylated NC is less able than wild-type to promote RNA annealing and participates in the initiation of reverse transcription PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • RMTs methylate histone arginines, organism-specific biosystem (from REACTOME)
      RMTs methylate histone arginines, organism-specific biosystemArginine methylation is a common post-translational modification; around 2% of arginine residues are methylated in rat liver nuclei (Boffa et al. 1977). Arginine can be methylated in 3 different ways...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10559, FLJ51477

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    base-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-R2 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4-R3 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of histone H3-K4 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of megakaryocyte differentiation TAS
    Traceable Author Statement
    more info
     
    regulation of signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 6
    Names
    HMT1 hnRNP methyltransferase-like 6
    heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
    histone-arginine N-methyltransferase PRMT6
    NP_060607.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018137.2NP_060607.2  protein arginine N-methyltransferase 6

      See identical proteins and their annotated locations for NP_060607.2

      Status: VALIDATED

      Source sequence(s)
      AI754232, AY043278, DA073209
      Consensus CDS
      CCDS41360.2
      UniProtKB/Swiss-Prot
      Q96LA8
      Related
      ENSP00000359095.1, ENST00000370078.1
      Conserved Domains (1) summary
      cl17173
      Location:67200
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      107056645..107059294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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