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    PPP2CB protein phosphatase 2 catalytic subunit beta [ Homo sapiens (human) ]

    Gene ID: 5516, updated on 5-Sep-2021

    Summary

    Official Symbol
    PPP2CBprovided by HGNC
    Official Full Name
    protein phosphatase 2 catalytic subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:9300
    See related
    Ensembl:ENSG00000104695 MIM:176916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP2CB; PP2Abeta
    Summary
    This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in brain (RPKM 83.4), thyroid (RPKM 78.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See PPP2CB in Genome Data Viewer
    Location:
    8p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30785616..30812818, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30643132..30670334, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8 Neighboring gene HIKESHI pseudogene 3 Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene uncharacterized LOC105379357 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    Vpu vpu IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-threonine dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lead ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein phosphatase type 2A complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Names
    PP2A-beta
    protein phosphatase 2, catalytic subunit, beta isozyme
    protein phosphatase type 2A catalytic subunit
    testicular tissue protein Li 146
    NP_001009552.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009552.2NP_001009552.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

      See identical proteins and their annotated locations for NP_001009552.1

      Status: REVIEWED

      Source sequence(s)
      AC009314, BC012022, BG716837, CA419001, CF594136
      Consensus CDS
      CCDS6079.1
      UniProtKB/Swiss-Prot
      P62714
      UniProtKB/TrEMBL
      A0A140VJS0
      Related
      ENSP00000221138.4, ENST00000221138.9
      Conserved Domains (1) summary
      cd07415
      Location:9293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      30785616..30812818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004156.2: Suppressed sequence

      Description
      NM_004156.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support a splice pattern with non-consensus splice sites in the 5' UTR.
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