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    MSTO1 misato mitochondrial distribution and morphology regulator 1 [ Homo sapiens (human) ]

    Gene ID: 55154, updated on 15-Jun-2019

    Summary

    Official Symbol
    MSTO1provided by HGNC
    Official Full Name
    misato mitochondrial distribution and morphology regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:29678
    See related
    Ensembl:ENSG00000125459 MIM:617619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST; MMYAT; LST005
    Expression
    Ubiquitous expression in testis (RPKM 18.6), fat (RPKM 12.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See MSTO1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155610170..155614967)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155579961..155584758)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene claudin 6 pseudogene Neighboring gene death associated protein 3 pseudogene 1 Neighboring gene uncharacterized LOC105371452 Neighboring gene gon-4 like pseudogene Neighboring gene gon-4 like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    MYOPATHY, MITOCHONDRIAL, AND ATAXIA
    MedGen: C4540096 OMIM: 617675 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10504, DKFZp686B1757, DKFZp686I01261

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion distribution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein misato homolog 1
    Names
    misato 1, mitochondrial distribution and morphology regulator
    misato homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256532.1NP_001243461.1  protein misato homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001243461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AF272833, AK222863, BC002535, DA807092
      UniProtKB/Swiss-Prot
      Q9BUK6
      Conserved Domains (1) summary
      cd06060
      Location:6562
      misato; Misato segment II tubulin-like domain
    2. NM_001256533.1NP_001243462.1  protein misato homolog 1 isoform c

      See identical proteins and their annotated locations for NP_001243462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AF272833, BC002535, CR749791, DA807092
      UniProtKB/Swiss-Prot
      Q9BUK6
      Conserved Domains (1) summary
      cd06060
      Location:6551
      misato; Misato segment II tubulin-like domain
    3. NM_001350772.1NP_001337701.1  protein misato homolog 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF272833, BC002535, CR749791, DA807092
      Related
      ENSP00000357325.4, ENST00000368341.8
      Conserved Domains (1) summary
      cd06060
      Location:6552
      misato; Misato segment II tubulin-like domain
    4. NM_001350773.1NP_001337702.1  protein misato homolog 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    5. NM_001350774.1NP_001337703.1  protein misato homolog 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA807092
      Related
      ENSP00000498188.1, ENST00000649846.1
      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    6. NM_001350775.1NP_001337704.1  protein misato homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BX421996, DA807092, H12094
      Conserved Domains (1) summary
      cd06060
      Location:6511
      misato; Misato segment II tubulin-like domain
    7. NM_001350776.1NP_001337705.1  protein misato homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BF027217, DA070565, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:88508
      misato; Misato segment II tubulin-like domain
    8. NM_001350777.1NP_001337706.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    9. NM_001350778.1NP_001337707.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA272145, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    10. NM_001350779.1NP_001337708.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA379275, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    11. NM_001350780.1NP_001337709.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    12. NM_001350781.1NP_001337710.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, AY334564, BC002535, DA070565, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    13. NM_001350782.1NP_001337711.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    14. NM_001350783.1NP_001337712.1  protein misato homolog 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:1384
      misato; Misato segment II tubulin-like domain
    15. NM_001350784.1NP_001337713.1  protein misato homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA379275, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain
    16. NM_001350785.1NP_001337714.1  protein misato homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, AY334564, BC002535, DA272145, DA379275, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain
    17. NM_001350786.1NP_001337715.1  protein misato homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA070565, DA272145, DA807092
      Conserved Domains (1) summary
      cl10017
      Location:1250
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    18. NM_001350787.1NP_001337716.1  protein misato homolog 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, CR749791, DA379275, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:7371
      misato; Misato segment II tubulin-like domain
    19. NM_001350788.1NP_001337717.1  protein misato homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
      Conserved Domains (1) summary
      cd06060
      Location:1333
      misato; Misato segment II tubulin-like domain
    20. NM_001350789.1NP_001337718.1  protein misato homolog 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
      Conserved Domains (1) summary
      cl10017
      Location:7330
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    21. NM_018116.3NP_060586.2  protein misato homolog 1 isoform a

      See identical proteins and their annotated locations for NP_060586.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF272833, AK001366, BC002535, DA807092
      Consensus CDS
      CCDS1114.1
      UniProtKB/Swiss-Prot
      Q9BUK6
      Related
      ENSP00000245564.2, ENST00000245564.6
      Conserved Domains (1) summary
      cd06060
      Location:6563
      misato; Misato segment II tubulin-like domain

    RNA

    1. NR_046292.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, AK297140, AK309573, AL353807, BC002535, DA807092
    2. NR_046293.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, AK309573, BC002535, DA807092
    3. NR_046294.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK056128, DA807092
      Related
      ENST00000494995.5
    4. NR_046295.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, BC002535, BX537684, DA807092
      Related
      ENST00000490743.5
    5. NR_146907.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA807092
    6. NR_146908.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BX421996, DA807092

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      155610170..155614967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448046.1XP_024303814.1  protein misato homolog 1 isoform X11

      Conserved Domains (1) summary
      cl10017
      Location:11251
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    2. XM_024448048.1XP_024303816.1  protein misato homolog 1 isoform X13

      Conserved Domains (1) summary
      cl10017
      Location:11335
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    3. XM_024448044.1XP_024303812.1  protein misato homolog 1 isoform X10

      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain
    4. XM_011509703.2XP_011508005.1  protein misato homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011508005.1

      Conserved Domains (1) summary
      cd06060
      Location:88508
      misato; Misato segment II tubulin-like domain
    5. XM_017001605.2XP_016857094.1  protein misato homolog 1 isoform X7

      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    6. XM_011509707.2XP_011508009.1  protein misato homolog 1 isoform X8

      See identical proteins and their annotated locations for XP_011508009.1

      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    7. XM_011509704.2XP_011508006.1  protein misato homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011508006.1

      Conserved Domains (1) summary
      cd06060
      Location:88508
      misato; Misato segment II tubulin-like domain
    8. XM_017001606.2XP_016857095.1  protein misato homolog 1 isoform X8

      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    9. XM_011509708.2XP_011508010.1  protein misato homolog 1 isoform X9

      See identical proteins and their annotated locations for XP_011508010.1

      UniProtKB/Swiss-Prot
      Q9BUK6
      Conserved Domains (1) summary
      cd06060
      Location:1384
      misato; Misato segment II tubulin-like domain
    10. XM_024448042.1XP_024303810.1  protein misato homolog 1 isoform X8

      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    11. XM_011509695.2XP_011507997.1  protein misato homolog 1 isoform X1

      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    12. XM_011509700.2XP_011508002.1  protein misato homolog 1 isoform X2

      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    13. XM_011509701.2XP_011508003.1  protein misato homolog 1 isoform X3

      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    14. XM_011509702.2XP_011508004.1  protein misato homolog 1 isoform X4

      Conserved Domains (1) summary
      cd06060
      Location:6512
      misato; Misato segment II tubulin-like domain
    15. XM_011509709.3XP_011508011.1  protein misato homolog 1 isoform X12

      Conserved Domains (1) summary
      cd06060
      Location:6366
      misato; Misato segment II tubulin-like domain
    16. XM_011509705.1XP_011508007.1  protein misato homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_011508007.1

      Conserved Domains (1) summary
      cd06060
      Location:88508
      misato; Misato segment II tubulin-like domain
    17. XM_024448039.1XP_024303807.1  protein misato homolog 1 isoform X6

      Conserved Domains (1) summary
      cd06060
      Location:1494
      misato; Misato segment II tubulin-like domain
    18. XM_024448043.1XP_024303811.1  protein misato homolog 1 isoform X10

      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain

    RNA

    1. XR_002956984.1 RNA Sequence

    2. XR_001737275.2 RNA Sequence

    3. XR_001737273.2 RNA Sequence

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