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    MTPAP mitochondrial poly(A) polymerase [ Homo sapiens (human) ]

    Gene ID: 55149, updated on 17-Jun-2019

    Summary

    Official Symbol
    MTPAPprovided by HGNC
    Official Full Name
    mitochondrial poly(A) polymeraseprovided by HGNC
    Primary source
    HGNC:HGNC:25532
    See related
    Ensembl:ENSG00000107951 MIM:613669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPD1; SPAX4; TENT6
    Summary
    The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 4.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See MTPAP in Genome Data Viewer
    Location:
    10p11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (30309801..30349338, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (30598730..30638267, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 598, pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 39 Neighboring gene dynamin 1 pseudogene 17 Neighboring gene GOLGA2 pseudogene 6 Neighboring gene RNA, 7SL, cytoplasmic 241, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10486

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    UTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polynucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    poly(A) RNA polymerase, mitochondrial
    Names
    PAP-associated domain-containing protein 1
    TUTase 1
    polynucleotide adenylyltransferase
    terminal uridylyltransferase 1
    NP_060579.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028096.1 RefSeqGene

      Range
      5001..44538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018109.3NP_060579.3  poly(A) RNA polymerase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_060579.3

      Status: REVIEWED

      Source sequence(s)
      AK001348, AL353796, DA086747
      Consensus CDS
      CCDS7165.1
      UniProtKB/Swiss-Prot
      Q9NVV4
      Related
      ENSP00000263063.3, ENST00000263063.8
      Conserved Domains (2) summary
      cd05402
      Location:206344
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:440483
      PAP_assoc; Cid1 family poly A polymerase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      30309801..30349338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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