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    HEATR1 HEAT repeat containing 1 [ Homo sapiens (human) ]

    Gene ID: 55127, updated on 17-Jun-2019

    Summary

    Official Symbol
    HEATR1provided by HGNC
    Official Full Name
    HEAT repeat containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25517
    See related
    Ensembl:ENSG00000119285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAP28; UTP10
    Expression
    Ubiquitous expression in testis (RPKM 12.5), appendix (RPKM 11.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See HEATR1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (236549005..236604516, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236712305..236767841, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LGALS8 antisense RNA 1 Neighboring gene uncharacterized LOC107985367 Neighboring gene galectin 8 Neighboring gene control region 3 heart enhancer Neighboring gene VISTA enhancer hs2135 Neighboring gene actinin alpha 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of HEAT repeat containing 1 (HEATR1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol HIV-1 IN is identified to have a physical interaction with HEAT repeat containing 1 (HEATR1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
      Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • rRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA modification in the nucleus and cytosol, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10359, MGC72083

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    membrane HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    t-UTP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    HEAT repeat-containing protein 1
    Names
    U3 small nucleolar RNA-associated protein 10 homolog
    UTP10, small subunit (SSU) processome component, homolog
    protein BAP28

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018072.6NP_060542.4  HEAT repeat-containing protein 1

      See identical proteins and their annotated locations for NP_060542.4

      Status: VALIDATED

      Source sequence(s)
      AK095692, AL359921, BC035302, BC065205, BC130000, BC150614, DB067322
      Consensus CDS
      CCDS31066.1
      UniProtKB/Swiss-Prot
      Q9H583
      UniProtKB/TrEMBL
      A2VDI1, B2RWN5
      Related
      ENSP00000355541.3, ENST00000366582.8
      Conserved Domains (2) summary
      smart01036
      Location:18572010
      BP28CT; BP28CT (NUC211) domain
      pfam12397
      Location:238354
      U3snoRNP10; U3 small nucleolar RNA-associated protein 10

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      236549005..236604516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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