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    SUSD4 sushi domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 55061, updated on 17-Jun-2019

    Summary

    Official Symbol
    SUSD4provided by HGNC
    Official Full Name
    sushi domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:25470
    See related
    Ensembl:ENSG00000143502 MIM:615827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO222
    Expression
    Biased expression in esophagus (RPKM 11.1), ovary (RPKM 10.5) and 13 other tissues See more
    Orthologs

    Genomic context

    See SUSD4 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (223220826..223365271, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223394161..223537564, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985323 Neighboring gene toll like receptor 5 Neighboring gene uncharacterized LOC105373025 Neighboring gene RNA, U4 small nuclear 57, pseudogene Neighboring gene coiled-coil domain containing 185

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10052

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of complement activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sushi domain-containing protein 4
    Names
    YHGM196
    testicular secretory protein Li 55

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037175.3NP_001032252.1  sushi domain-containing protein 4 isoform b precursor

      See identical proteins and their annotated locations for NP_001032252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC004888, DA125047
      Consensus CDS
      CCDS31034.1
      UniProtKB/Swiss-Prot
      Q5VX71
      UniProtKB/TrEMBL
      A0A140VK55
      Related
      ENSP00000339926.6, ENST00000344029.6
      Conserved Domains (1) summary
      cl27761
      Location:30238
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    2. NM_017982.4NP_060452.3  sushi domain-containing protein 4 isoform a precursor

      See identical proteins and their annotated locations for NP_060452.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK096265, AY358495, BF446433, DA125047
      Consensus CDS
      CCDS41471.1
      UniProtKB/Swiss-Prot
      Q5VX71
      UniProtKB/TrEMBL
      B3KTY0
      Related
      ENSP00000355843.4, ENST00000366878.9
      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54296
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      223220826..223365271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447937.1XP_024303705.1  sushi domain-containing protein 4 isoform X5

    2. XM_024447936.1XP_024303704.1  sushi domain-containing protein 4 isoform X4

    3. XM_017001583.1XP_016857072.1  sushi domain-containing protein 4 isoform X1

    4. XM_017001584.1XP_016857073.1  sushi domain-containing protein 4 isoform X2

    5. XM_006711408.2XP_006711471.1  sushi domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_006711471.1

      Related
      ENSP00000477432.1, ENST00000608996.5
      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54298
      PHA02927; secreted complement-binding protein; Provisional
    6. XM_005273172.1XP_005273229.1  sushi domain-containing protein 4 isoform X8

      See identical proteins and their annotated locations for XP_005273229.1

      UniProtKB/TrEMBL
      B7Z469
      Conserved Domains (2) summary
      cd00033
      Location:2077
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:83137
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    7. XM_011509687.1XP_011507989.1  sushi domain-containing protein 4 isoform X7

      Conserved Domains (2) summary
      cd00033
      Location:2077
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:85139
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    8. XM_017001587.1XP_016857076.1  sushi domain-containing protein 4 isoform X5

      UniProtKB/Swiss-Prot
      Q5VX71
      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54296
      PHA02927; secreted complement-binding protein; Provisional
    9. XM_005273169.1XP_005273226.1  sushi domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_005273226.1

      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54298
      PHA02927; secreted complement-binding protein; Provisional
    10. XM_017001585.1XP_016857074.1  sushi domain-containing protein 4 isoform X3

    11. XM_017001588.1XP_016857077.1  sushi domain-containing protein 4 isoform X5

      UniProtKB/Swiss-Prot
      Q5VX71
      Related
      ENSP00000344219.3, ENST00000343846.7
      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:243297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54296
      PHA02927; secreted complement-binding protein; Provisional
    12. XM_011509685.1XP_011507987.1  sushi domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011507987.1

      Conserved Domains (3) summary
      cd00033
      Location:180237
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:245299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:54298
      PHA02927; secreted complement-binding protein; Provisional
    13. XM_017001586.1XP_016857075.1  sushi domain-containing protein 4 isoform X3

    14. XM_024447940.1XP_024303708.1  sushi domain-containing protein 4 isoform X9

      Conserved Domains (1) summary
      cl27761
      Location:30238
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    15. XM_017001589.1XP_016857078.1  sushi domain-containing protein 4 isoform X6

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