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    PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 [ Homo sapiens (human) ]

    Gene ID: 5504, updated on 17-Jun-2019

    Summary

    Official Symbol
    PPP1R2provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory inhibitor subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:9288
    See related
    Ensembl:ENSG00000184203 MIM:601792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IPP2; IPP-2; PPP1R2A
    Summary
    Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See PPP1R2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195514422..195543401, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195241221..195270224, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene RNA, U6 small nuclear 25, pseudogene Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene RNA, U6atac small nuclear 24, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene Neighboring gene ribosomal protein L24 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC87148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein phosphatase inhibitor 2
    Names
    phosphoprotein phosphatase
    NP_001278433.1
    NP_001278434.1
    NP_001303254.1
    NP_006232.1
    XP_006713745.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291504.2NP_001278433.1  protein phosphatase inhibitor 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC069213
      Conserved Domains (1) summary
      pfam04979
      Location:45164
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    2. NM_001291505.2NP_001278434.1  protein phosphatase inhibitor 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC069213
      Related
      ENSP00000400238.1, ENST00000438848.5
      Conserved Domains (1) summary
      pfam04979
      Location:45137
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    3. NM_001316325.2NP_001303254.1  protein phosphatase inhibitor 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC069213, BC007655, BI560631
      UniProtKB/Swiss-Prot
      P41236
      Conserved Domains (1) summary
      pfam04979
      Location:52143
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    4. NM_006241.8NP_006232.1  protein phosphatase inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_006232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA259068, AC069213, BC007655
      Consensus CDS
      CCDS3309.1
      UniProtKB/Swiss-Prot
      P41236
      Related
      ENSP00000484580.1, ENST00000618156.5
      Conserved Domains (1) summary
      pfam04979
      Location:45164
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    RNA

    1. NR_133014.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC069213, AI638626, BC007655, BI549862

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      195514422..195543401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713682.3XP_006713745.1  protein phosphatase inhibitor 2 isoform X1

      Conserved Domains (1) summary
      pfam04979
      Location:45139
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
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