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    LPCAT2 lysophosphatidylcholine acyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 54947, updated on 12-Oct-2019

    Summary

    Official Symbol
    LPCAT2provided by HGNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:26032
    See related
    Ensembl:ENSG00000087253 MIM:612040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AYTL1; AGPAT11; LysoPAFAT
    Summary
    This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues See more
    Orthologs

    Genomic context

    See LPCAT2 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (55509055..55586666)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (55542913..55620582)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MMP2 antisense RNA 1 Neighboring gene matrix metallopeptidase 2 Neighboring gene calpain small subunit 2 Neighboring gene solute carrier family 6 member 2 Neighboring gene uncharacterized LOC105371280

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20481, DKFZp686H22112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    1-acylglycerophosphocholine O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    1-alkylglycerophosphocholine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylcholine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    platelet activating factor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase 2
    Names
    1-AGP acyltransferase 11
    1-AGPAT 11
    1-acylglycerol-3-phosphate O-acyltransferase 11
    1-acylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPAAT-alpha
    LPC acyltransferase 2
    LPCAT-2
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyl-CoA:lysophosphatidylcholine acyltransferase 2
    acyltransferase-like 1
    lyso-PAF acetyltransferase
    lyso-platelet-activating factor (PAF) acetyltransferase
    lysoPC acyltransferase 2
    lysophosphatidic acid acyltransferase alpha
    NP_060309.2
    XP_005256063.1
    XP_011521471.1
    XP_016878865.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017839.5NP_060309.2  lysophosphatidylcholine acyltransferase 2

      See identical proteins and their annotated locations for NP_060309.2

      Status: REVIEWED

      Source sequence(s)
      AI915099, AW366682, BC002472, BC005981, BX641069
      Consensus CDS
      CCDS10753.1
      UniProtKB/Swiss-Prot
      Q7L5N7
      Related
      ENSP00000262134.5, ENST00000262134.10
      Conserved Domains (2) summary
      cd07991
      Location:116327
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      cl25352
      Location:374494
      EFh_PEF; The penta-EF hand (PEF) family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      55509055..55586666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256006.3XP_005256063.1  lysophosphatidylcholine acyltransferase 2 isoform X2

      Conserved Domains (2) summary
      cd07991
      Location:116287
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:103254
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    2. XM_017023376.1XP_016878865.1  lysophosphatidylcholine acyltransferase 2 isoform X1

      Conserved Domains (4) summary
      cd07991
      Location:60271
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:47198
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:340402
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:340401
      EF-hand_7; EF-hand domain pair
    3. XM_011523169.3XP_011521471.1  lysophosphatidylcholine acyltransferase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q7L5N7
      Conserved Domains (3) summary
      cd00051
      Location:126188
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:126187
      EF-hand_7; EF-hand domain pair
      cl17185
      Location:257
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
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