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    ZSCAN32 zinc finger and SCAN domain containing 32 [ Homo sapiens (human) ]

    Gene ID: 54925, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZSCAN32provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 32provided by HGNC
    Primary source
    HGNC:HGNC:20812
    See related
    Ensembl:ENSG00000140987 AllianceGenome:HGNC:20812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCCS-5; ZNF434
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.7), lymph node (RPKM 4.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZSCAN32 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3382085..3401004, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3409098..3428275, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3432085..3451004, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-ND1 pseudogene 8 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3450765-3451264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7133 Neighboring gene zinc finger protein 174 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3470303-3470585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3481451-3481952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7134 Neighboring gene zinc finger protein 597

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4179, FLJ20417, FLJ31901, FLJ56278

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 32
    Names
    human cervical cancer suppressor gene 5 protein
    zinc finger protein 434

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284527.2NP_001271456.1  zinc finger and SCAN domain-containing protein 32 isoform a

      See identical proteins and their annotated locations for NP_001271456.1

      Status: VALIDATED

      Source sequence(s)
      AK291213, AY261676
      Consensus CDS
      CCDS66921.1
      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
      Related
      ENSP00000380061.4, ENST00000396852.9
      Conserved Domains (8) summary
      smart00431
      Location:33142
      SCAN; leucine rich region
      COG5048
      Location:455668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:522543
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33121
      SCAN; SCAN domain
      pfam13465
      Location:591616
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:253334
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:218250
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    2. NM_001284528.2NP_001271457.1  zinc finger and SCAN domain-containing protein 32 isoform c

      See identical proteins and their annotated locations for NP_001271457.1

      Status: VALIDATED

      Source sequence(s)
      AK056463, AK291213, AY261676
      Consensus CDS
      CCDS66920.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000483210.1, ENST00000618425.4
      Conserved Domains (5) summary
      COG5048
      Location:230379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:233254
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:302327
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:145
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    3. NM_001284529.2NP_001271458.1  zinc finger and SCAN domain-containing protein 32 isoform c

      See identical proteins and their annotated locations for NP_001271458.1

      Status: VALIDATED

      Source sequence(s)
      AC025283, AK301586, AY261676
      Consensus CDS
      CCDS66920.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000391787.2, ENST00000439568.2
      Conserved Domains (5) summary
      COG5048
      Location:230379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:233254
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:302327
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:145
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    4. NM_001324340.2NP_001311269.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    5. NM_001324341.2NP_001311270.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    6. NM_001324342.2NP_001311271.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    7. NM_001324343.2NP_001311272.1  zinc finger and SCAN domain-containing protein 32 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC025283
    8. NM_001324344.2NP_001311273.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    9. NM_001324345.2NP_001311274.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    10. NM_001324346.2NP_001311275.1  zinc finger and SCAN domain-containing protein 32 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Conserved Domains (7) summary
      smart00431
      Location:33142
      SCAN; leucine rich region
      COG5048
      Location:382595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:450470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:449470
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33121
      SCAN; SCAN domain
      pfam13465
      Location:518543
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:180261
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    11. NM_017810.4NP_060280.2  zinc finger and SCAN domain-containing protein 32 isoform b

      See identical proteins and their annotated locations for NP_060280.2

      Status: VALIDATED

      Source sequence(s)
      AY261676
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000302502.3, ENST00000304926.7
      Conserved Domains (6) summary
      COG5048
      Location:307456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:638
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3382085..3401004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023371.3XP_016878860.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
      Conserved Domains (8) summary
      smart00431
      Location:33142
      SCAN; leucine rich region
      COG5048
      Location:455668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:522543
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33121
      SCAN; SCAN domain
      pfam13465
      Location:591616
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:253334
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:218250
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    2. XM_047434275.1XP_047290231.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3409098..3428275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380581.1XP_054236556.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    2. XM_054380578.1XP_054236553.1  zinc finger and SCAN domain-containing protein 32 isoform X3

    3. XM_054380576.1XP_054236551.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
    4. XM_054380579.1XP_054236554.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    5. XM_054380577.1XP_054236552.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
    6. XM_054380582.1XP_054236557.1  zinc finger and SCAN domain-containing protein 32 isoform X4

      UniProtKB/TrEMBL
      I3L2L7
    7. XM_054380580.1XP_054236555.1  zinc finger and SCAN domain-containing protein 32 isoform X2