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    GON4L gon-4 like [ Homo sapiens (human) ]

    Gene ID: 54856, updated on 7-Jul-2019

    Summary

    Official Symbol
    GON4Lprovided by HGNC
    Official Full Name
    gon-4 likeprovided by HGNC
    Primary source
    HGNC:HGNC:25973
    See related
    Ensembl:ENSG00000116580 MIM:610393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GON4; YARP; GON-4
    Expression
    Ubiquitous expression in testis (RPKM 11.0), spleen (RPKM 8.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See GON4L in Genome Data Viewer
    Location:
    1q22
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155749658..155859426, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155719450..155829185, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene YY1 associated protein 1 Neighboring gene death associated protein 3 Neighboring gene uncharacterized LOC100505728 Neighboring gene misato family member 2, pseudogene Neighboring gene small Cajal body-specific RNA 26B Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene synaptotagmin 11 Neighboring gene Ras like without CAAX 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12923, FLJ20203, FLJ23040, KIAA1606, MGC138817, MGC138818, DKFZp761I241, RP11-101O6.1, RP11-243J18.4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    GON-4-like protein
    Names
    2610100B20Rik
    YY1AP related protein
    YY1AP-related protein1
    gon-4 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282856.1NP_001269785.1  GON-4-like protein isoform c

      See identical proteins and their annotated locations for NP_001269785.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 3 and 4 encode the same, longest protein (isoform c).
      Source sequence(s)
      AL162734, AY335491, CN391065
      Consensus CDS
      CCDS60296.1
      UniProtKB/Swiss-Prot
      Q3T8J9
      Related
      ENSP00000483100.1, ENST00000615926.4
      Conserved Domains (2) summary
      cd12202
      Location:21432208
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16481693
      PAH; Paired amphipathic helix repeat
    2. NM_001282858.2NP_001269787.1  GON-4-like protein isoform a

      See identical proteins and their annotated locations for NP_001269787.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform a), compared to isoform c.
      Source sequence(s)
      AB195687, AL162734, BC064933, BC114629, CN391065
      Consensus CDS
      CCDS44242.1
      UniProtKB/Swiss-Prot
      Q3T8J9
      UniProtKB/TrEMBL
      A4PB67
      Conserved Domains (2) summary
      cd12202
      Location:21422207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16481693
      PAH; Paired amphipathic helix repeat
    3. NM_001282860.1NP_001269789.1  GON-4-like protein isoform c

      See identical proteins and their annotated locations for NP_001269789.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein. Variants 3 and 4 encode isoform (c).
      Source sequence(s)
      AB195687, AL162734, AY335490, CN391065
      Consensus CDS
      CCDS60296.1
      UniProtKB/Swiss-Prot
      Q3T8J9
      UniProtKB/TrEMBL
      A4PB67
      Related
      ENSP00000357315.1, ENST00000368331.5
      Conserved Domains (2) summary
      cd12202
      Location:21432208
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16481693
      PAH; Paired amphipathic helix repeat
    4. NM_001282861.2NP_001269790.1  GON-4-like protein isoform b

      See identical proteins and their annotated locations for NP_001269790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AB195687, AI476308, AK022985, AL139128, BC036740, BC115703
      Consensus CDS
      CCDS1121.1
      UniProtKB/Swiss-Prot
      Q3T8J9
      UniProtKB/TrEMBL
      A4PB67, Q14BN2, Q9H986
      Related
      ENSP00000478593.1, ENST00000622608.1
      Conserved Domains (1) summary
      PHA03247
      Location:10071436
      PHA03247; large tegument protein UL36; Provisional
    5. NM_032292.6NP_115668.4  GON-4-like protein isoform b

      See identical proteins and their annotated locations for NP_115668.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains a 3' terminal exon that extends past a splice site in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AB195688, AI476308, AL139128, BC036740, BC114629
      Consensus CDS
      CCDS1121.1
      UniProtKB/Swiss-Prot
      Q3T8J9
      UniProtKB/TrEMBL
      A4PB68
      Related
      ENSP00000354322.5, ENST00000361040.9
      Conserved Domains (1) summary
      PHA03247
      Location:10071436
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      155749658..155859426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711394.4XP_006711457.1  GON-4-like protein isoform X1

      See identical proteins and their annotated locations for XP_006711457.1

      UniProtKB/Swiss-Prot
      Q3T8J9
      Related
      ENSP00000396117.1, ENST00000437809.5
      Conserved Domains (2) summary
      cd12202
      Location:21422207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16481693
      PAH; Paired amphipathic helix repeat
    2. XM_006711393.3XP_006711456.1  GON-4-like protein isoform X1

      See identical proteins and their annotated locations for XP_006711456.1

      UniProtKB/Swiss-Prot
      Q3T8J9
      Related
      ENSP00000271883.5, ENST00000271883.9
      Conserved Domains (2) summary
      cd12202
      Location:21422207
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16481693
      PAH; Paired amphipathic helix repeat
    3. XM_011509658.2XP_011507960.1  GON-4-like protein isoform X2

      Conserved Domains (2) summary
      cd12202
      Location:21132178
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:16191664
      PAH; Paired amphipathic helix repeat
    4. XM_005245284.3XP_005245341.1  GON-4-like protein isoform X3

      See identical proteins and their annotated locations for XP_005245341.1

      Conserved Domains (2) summary
      cd12202
      Location:19702035
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:14761521
      PAH; Paired amphipathic helix repeat
    5. XM_011509659.2XP_011507961.1  GON-4-like protein isoform X3

      See identical proteins and their annotated locations for XP_011507961.1

      Conserved Domains (2) summary
      cd12202
      Location:19702035
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:14761521
      PAH; Paired amphipathic helix repeat
    6. XM_005245286.3XP_005245343.1  GON-4-like protein isoform X4

      Conserved Domains (2) summary
      cd12202
      Location:13381403
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:844889
      PAH; Paired amphipathic helix repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037533.1: Suppressed sequence

      Description
      NM_001037533.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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