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    ZRANB1 zinc finger RANBP2-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 54764, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZRANB1provided by HGNC
    Official Full Name
    zinc finger RANBP2-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18224
    See related
    Ensembl:ENSG00000019995 MIM:611749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRABID
    Expression
    Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZRANB1 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124939489..124988189)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126605704..126676005)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene uncharacterized LOC107984160 Neighboring gene nucleophosmin 1 pseudogene 31 Neighboring gene C-terminal binding protein 2 Neighboring gene microRNA 4296 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
      Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp762P2216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K29-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K29-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K33-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K33-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin thioesterase ZRANB1
    Names
    TRAF-binding domain-containing protein
    TRAF-binding protein domain
    hTrabid
    zinc finger Ran-binding domain-containing protein 1
    zinc finger, RAN-binding domain containing 1
    NP_060050.2
    XP_006717970.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017580.3NP_060050.2  ubiquitin thioesterase ZRANB1

      See identical proteins and their annotated locations for NP_060050.2

      Status: VALIDATED

      Source sequence(s)
      AJ252060, AL731571, AL832925
      Consensus CDS
      CCDS7642.1
      UniProtKB/Swiss-Prot
      Q9UGI0
      Related
      ENSP00000352676.4, ENST00000359653.4
      Conserved Domains (3) summary
      smart00547
      Location:152175
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:88107
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:438586
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      124939489..124988189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717907.2XP_006717970.1  ubiquitin thioesterase ZRANB1 isoform X1

      See identical proteins and their annotated locations for XP_006717970.1

      Conserved Domains (3) summary
      smart00547
      Location:178201
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:114133
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:464612
      OTU; OTU-like cysteine protease
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