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    ZRANB1 zinc finger RANBP2-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 54764, updated on 4-Dec-2022

    Summary

    Official Symbol
    ZRANB1provided by HGNC
    Official Full Name
    zinc finger RANBP2-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18224
    See related
    Ensembl:ENSG00000019995 MIM:611749; AllianceGenome:HGNC:18224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRABID
    Summary
    Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZRANB1 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (124916894..124988189)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (125823167..125869209)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126630692..126676758)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene nucleophosmin 1 pseudogene 31 Neighboring gene uncharacterized LOC124902520 Neighboring gene C-terminal binding protein 2 Neighboring gene microRNA 4296

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp762P2216

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K29-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K29-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K33-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K33-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin thioesterase ZRANB1
    Names
    TRAF-binding domain-containing protein
    TRAF-binding protein domain
    hTrabid
    zinc finger Ran-binding domain-containing protein 1
    zinc finger, RAN-binding domain containing 1
    NP_060050.2
    XP_006717970.1
    XP_047281339.1
    XP_047281340.1
    XP_047281341.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017580.3NP_060050.2  ubiquitin thioesterase ZRANB1

      See identical proteins and their annotated locations for NP_060050.2

      Status: VALIDATED

      Source sequence(s)
      AJ252060, AL731571, AL832925
      Consensus CDS
      CCDS7642.1
      UniProtKB/Swiss-Prot
      Q69YK3, Q9UGI0
      Related
      ENSP00000352676.4, ENST00000359653.4
      Conserved Domains (4) summary
      smart00547
      Location:152175
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:88107
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:438586
      OTU; OTU-like cysteine protease
      pfam18418
      Location:246341
      AnkUBD; Ankyrin ubiquitin-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      124916894..124988189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717907.3XP_006717970.1  ubiquitin thioesterase ZRANB1 isoform X1

      See identical proteins and their annotated locations for XP_006717970.1

      Conserved Domains (4) summary
      smart00547
      Location:178201
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:114133
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam02338
      Location:464612
      OTU; OTU-like cysteine protease
      pfam18418
      Location:272367
      AnkUBD; Ankyrin ubiquitin-binding domain
    2. XM_047425383.1XP_047281339.1  ubiquitin thioesterase ZRANB1 isoform X2

      UniProtKB/Swiss-Prot
      Q69YK3
    3. XM_047425384.1XP_047281340.1  ubiquitin thioesterase ZRANB1 isoform X2

      UniProtKB/Swiss-Prot
      Q69YK3
    4. XM_047425385.1XP_047281341.1  ubiquitin thioesterase ZRANB1 isoform X2

      UniProtKB/Swiss-Prot
      Q69YK3

    RNA

    1. XR_007061968.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      125823167..125869209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)