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    ROPN1 rhophilin associated tail protein 1 [ Homo sapiens (human) ]

    Gene ID: 54763, updated on 17-Jun-2019

    Summary

    Official Symbol
    ROPN1provided by HGNC
    Official Full Name
    rhophilin associated tail protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17692
    See related
    Ensembl:ENSG00000065371 MIM:611757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT91; ODF6; ROPN1A; RHPNAP1; ropporin
    Summary
    The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Restricted expression toward testis (RPKM 42.1) See more
    Orthologs

    Genomic context

    See ROPN1 in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (123968521..123992170, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123687862..123711017, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin RhoGEF kinase Neighboring gene microRNA 5002 Neighboring gene ribosomal protein L7 pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystemRhotekin (RTKN) is a protein with an N-terminally located RHO GTPase binding domain, that shares a limited sequence homology with PKNs and rhophilins. RTKN binds to GTP-bound RHOA, RHOB and RHOC and ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434B1222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus HDA PubMed 

    General protein information

    Preferred Names
    ropporin-1A
    Names
    cancer/testis antigen 91
    outer dense fiber of sperm tails 6
    rhophilin-associated protein 1A
    ropporin, rhophilin associated protein 1
    testis secretory sperm-binding protein Li 239w

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317774.1NP_001304703.1  ropporin-1A isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BG219480, BG724071, HY055534
      Consensus CDS
      CCDS3026.1
      UniProtKB/Swiss-Prot
      Q9HAT0
      UniProtKB/TrEMBL
      A0A140VKB2
      Related
      ENSP00000385919.3, ENST00000405845.7
      Conserved Domains (1) summary
      cl02594
      Location:1046
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. NM_001317775.1NP_001304704.1  ropporin-1A isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BG219480, BG722939, HY055534
    3. NM_017578.4NP_060048.2  ropporin-1A isoform a

      See identical proteins and their annotated locations for NP_060048.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC117381, AF303889, BG219480
      Consensus CDS
      CCDS3026.1
      UniProtKB/Swiss-Prot
      Q9HAT0
      UniProtKB/TrEMBL
      A0A140VKB2
      Related
      ENSP00000184183.4, ENST00000184183.8
      Conserved Domains (1) summary
      cl02594
      Location:1046
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RNA

    1. NR_133916.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC117381, BC067767, HY055534
      Related
      ENST00000479867.1
    2. NR_133917.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC111005, HY055534
      Related
      ENST00000459660.5
    3. NR_133918.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL133624, DB042884, HY055534
    4. NR_133919.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK310283, AL133624, HY055534

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      123968521..123992170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512933.2XP_011511235.1  ropporin-1A isoform X1

      See identical proteins and their annotated locations for XP_011511235.1

      UniProtKB/Swiss-Prot
      Q9HAT0
      UniProtKB/TrEMBL
      A0A140VKB2
      Conserved Domains (1) summary
      cl02594
      Location:1046
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    2. XM_011512934.2XP_011511236.1  ropporin-1A isoform X1

      See identical proteins and their annotated locations for XP_011511236.1

      UniProtKB/Swiss-Prot
      Q9HAT0
      UniProtKB/TrEMBL
      A0A140VKB2
      Conserved Domains (1) summary
      cl02594
      Location:1046
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
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