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    PPARD peroxisome proliferator activated receptor delta [ Homo sapiens (human) ]

    Gene ID: 5467, updated on 11-Apr-2024

    Summary

    Official Symbol
    PPARDprovided by HGNC
    Official Full Name
    peroxisome proliferator activated receptor deltaprovided by HGNC
    Primary source
    HGNC:HGNC:9235
    See related
    Ensembl:ENSG00000112033 MIM:600409; AllianceGenome:HGNC:9235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
    Summary
    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPARD in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35342558..35428178)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35165619..35251256)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35310335..35395955)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17087 Neighboring gene zinc finger protein 76 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:35253595-35254794 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35263932-35264096 Neighboring gene Sharpr-MPRA regulatory region 9100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35280323-35280822 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24399 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35328305-35329201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35351066-35351668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35359676-35360244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35378432-35378965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35378966-35379498 Neighboring gene Sharpr-MPRA regulatory region 9405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17092 Neighboring gene makorin ring finger protein 6, pseudogene Neighboring gene FA complementation group E

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    EBI GWAS Catalog
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    EBI GWAS Catalog
    Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta PubMed
    vpr HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells PubMed
    vpr HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells PubMed
    vpr HIV-1 Vpr physically interacts with the LXXLL motif (residues 64-68) of PPARbeta/delta in vivo and in vitro and enhances PPARbeta/delta-induced transcription activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3931

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables linoleic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear steroid receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon ensheathment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in decidualization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in energy homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in glucose transmembrane transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of miRNA transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of skeletal muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of skeletal muscle satellite cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    part_of chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    PPAR-beta
    PPAR-delta
    PPARD/MYO1D fusion
    nuclear hormone receptor 1
    nuclear receptor subfamily 1 group C member 2
    peroxisome proliferator-activated receptor beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012345.2 RefSeqGene

      Range
      5001..90621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171818.2NP_001165289.1  peroxisome proliferator-activated receptor delta isoform 1

      See identical proteins and their annotated locations for NP_001165289.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AB099507, AK122614, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS4803.1
      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Related
      ENSP00000310928.4, ENST00000311565.4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. NM_001171819.2NP_001165290.1  peroxisome proliferator-activated receptor delta isoform 3

      See identical proteins and their annotated locations for NP_001165290.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK122614, AK296425, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS54994.1
      UniProtKB/TrEMBL
      B4E2Y1
      Related
      ENSP00000414372.2, ENST00000448077.6
      Conserved Domains (2) summary
      cd06932
      Location:134401
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:34117
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    3. NM_001171820.2NP_001165291.1  peroxisome proliferator-activated receptor delta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK122614, AK304878, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS54995.1
      UniProtKB/TrEMBL
      B4E2Y1
      Related
      ENSP00000413314.2, ENST00000418635.6
      Conserved Domains (2) summary
      cd06932
      Location:75342
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:4158
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_006238.5NP_006229.1  peroxisome proliferator-activated receptor delta isoform 1

      See identical proteins and their annotated locations for NP_006229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK122614, BE503383, DA192442
      Consensus CDS
      CCDS4803.1
      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Related
      ENSP00000353916.3, ENST00000360694.8
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    5. NM_177435.3NP_803184.1  peroxisome proliferator-activated receptor delta isoform 2

      See identical proteins and their annotated locations for NP_803184.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region and 3'UTR. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL022721, BC002715, CN332566, DA192442, DA476590
      Consensus CDS
      CCDS4804.1
      UniProtKB/TrEMBL
      F1D8S7
      Related
      ENSP00000337063.2, ENST00000337400.6
      Conserved Domains (2) summary
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:173359
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      35342558..35428178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418925.1XP_047274881.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    2. XM_017010974.2XP_016866463.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    3. XM_005249193.2XP_005249250.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_005249250.1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    4. XM_047418919.1XP_047274875.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    5. XM_047418922.1XP_047274878.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    6. XM_047418929.1XP_047274885.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    7. XM_011514707.2XP_011513009.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_011513009.1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    8. XM_047418935.1XP_047274891.1  peroxisome proliferator-activated receptor delta isoform X2

    9. XM_047418923.1XP_047274879.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    10. XM_047418920.1XP_047274876.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    11. XM_047418921.1XP_047274877.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    12. XM_047418930.1XP_047274886.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    13. XM_047418934.1XP_047274890.1  peroxisome proliferator-activated receptor delta isoform X2

    14. XM_047418924.1XP_047274880.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    15. XM_047418915.1XP_047274871.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    16. XM_011514710.2XP_011513012.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_011513012.1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    17. XM_047418917.1XP_047274873.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    18. XM_047418928.1XP_047274884.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    19. XM_047418918.1XP_047274874.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    20. XM_047418916.1XP_047274872.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    21. XM_017010973.2XP_016866462.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    22. XM_047418933.1XP_047274889.1  peroxisome proliferator-activated receptor delta isoform X2

    23. XM_047418932.1XP_047274888.1  peroxisome proliferator-activated receptor delta isoform X2

    24. XM_006715123.2XP_006715186.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_006715186.1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    25. XM_047418936.1XP_047274892.1  peroxisome proliferator-activated receptor delta isoform X2

    26. XM_047418927.1XP_047274883.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    27. XM_047418937.1XP_047274893.1  peroxisome proliferator-activated receptor delta isoform X2

    28. XM_047418931.1XP_047274887.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    29. XM_047418926.1XP_047274882.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    30. XM_024446474.2XP_024302242.1  peroxisome proliferator-activated receptor delta isoform X2

      Conserved Domains (2) summary
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:173359
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      35165619..35251256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355721.1XP_054211696.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    2. XM_054355712.1XP_054211687.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    3. XM_054355713.1XP_054211688.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    4. XM_054355707.1XP_054211682.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    5. XM_054355719.1XP_054211694.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    6. XM_054355706.1XP_054211681.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    7. XM_054355725.1XP_054211700.1  peroxisome proliferator-activated receptor delta isoform X2

    8. XM_054355710.1XP_054211685.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    9. XM_054355708.1XP_054211683.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    10. XM_054355709.1XP_054211684.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    11. XM_054355720.1XP_054211695.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    12. XM_054355724.1XP_054211699.1  peroxisome proliferator-activated receptor delta isoform X2

    13. XM_054355711.1XP_054211686.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    14. XM_054355701.1XP_054211676.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    15. XM_054355703.1XP_054211678.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    16. XM_054355704.1XP_054211679.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    17. XM_054355717.1XP_054211692.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    18. XM_054355705.1XP_054211680.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    19. XM_054355702.1XP_054211677.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    20. XM_054355718.1XP_054211693.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    21. XM_054355723.1XP_054211698.1  peroxisome proliferator-activated receptor delta isoform X2

    22. XM_054355722.1XP_054211697.1  peroxisome proliferator-activated receptor delta isoform X2

    23. XM_054355715.1XP_054211690.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    24. XM_054355727.1XP_054211702.1  peroxisome proliferator-activated receptor delta isoform X2

    25. XM_054355728.1XP_054211703.1  peroxisome proliferator-activated receptor delta isoform X2

    26. XM_054355716.1XP_054211691.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4
    27. XM_054355726.1XP_054211701.1  peroxisome proliferator-activated receptor delta isoform X2

    28. XM_054355714.1XP_054211689.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4