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    WDR5B WD repeat domain 5B [ Homo sapiens (human) ]

    Gene ID: 54554, updated on 17-Jun-2019

    Summary

    Official Symbol
    WDR5Bprovided by HGNC
    Official Full Name
    WD repeat domain 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:17826
    See related
    Ensembl:ENSG00000196981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See WDR5B in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122411846..122416062, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122130700..122134882, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cystatin A Neighboring gene HNF4 motif-containing MPRA enhancer 1/2 Neighboring gene coiled-coil domain containing 58 Neighboring gene family with sequence similarity 162 member A Neighboring gene uncharacterized LOC102723582 Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC107984000

    Genomic regions, transcripts, and products

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11287, MGC49879

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    histone H3-K4 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 5B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019069.4NP_061942.2  WD repeat-containing protein 5B

      See identical proteins and their annotated locations for NP_061942.2

      Status: REVIEWED

      Source sequence(s)
      AA310178, AA587370, AC083798, BC025762, BC043494, BU678251
      Consensus CDS
      CCDS3012.1
      UniProtKB/Swiss-Prot
      Q86VZ2
      Related
      ENSP00000330381.4, ENST00000330689.5
      Conserved Domains (2) summary
      cd00200
      Location:33326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4481
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      122411846..122416062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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