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    Sept1 septin 1 [ Mus musculus (house mouse) ]

    Gene ID: 54204, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sept1provided by MGI
    Official Full Name
    septin 1provided by MGI
    Primary source
    MGI:MGI:1858916
    See related
    Ensembl:ENSMUSG00000000486 Vega:OTTMUSG00000022181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Diff6; Pnutl3
    Expression
    Biased expression in thymus adult (RPKM 117.3), spleen adult (RPKM 47.0) and 1 other tissue See more
    Orthologs

    Genomic context

    See Sept1 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (127214442..127232987, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134357956..134361959, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10b Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene zinc finger protein 771

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    meiotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin filament array IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    septin-1
    Names
    differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)
    differentiation protein 6
    peanut-like protein 3
    protein Diff6
    NP_059489.2
    XP_006508092.1
    XP_006508093.1
    XP_006508094.1
    XP_006508095.1
    XP_011240164.1
    XP_011240165.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017461.2NP_059489.2  septin-1

      See identical proteins and their annotated locations for NP_059489.2

      Status: VALIDATED

      Source sequence(s)
      AI465014, AV507599, AW487826, BB610735, BX523183
      Consensus CDS
      CCDS40141.1
      UniProtKB/Swiss-Prot
      P42209
      Related
      ENSMUSP00000101921.1, OTTMUSP00000025010, ENSMUST00000106314.7, OTTMUST00000052670
      Conserved Domains (2) summary
      COG5019
      Location:5348
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:22295
      Septin; Septin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      127214442..127232987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508031.3XP_006508094.1  septin-1 isoform X2

      See identical proteins and their annotated locations for XP_006508094.1

      UniProtKB/TrEMBL
      D3Z3V3
      Conserved Domains (1) summary
      pfam00735
      Location:1267
      Septin; Septin
    2. XM_006508029.3XP_006508092.1  septin-1 isoform X1

      See identical proteins and their annotated locations for XP_006508092.1

      Conserved Domains (2) summary
      COG5019
      Location:5424
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:22371
      Septin; Septin
    3. XM_011241862.1XP_011240164.1  septin-1 isoform X1

      See identical proteins and their annotated locations for XP_011240164.1

      Conserved Domains (2) summary
      COG5019
      Location:5424
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:22371
      Septin; Septin
    4. XM_006508030.2XP_006508093.1  septin-1 isoform X2

      See identical proteins and their annotated locations for XP_006508093.1

      UniProtKB/TrEMBL
      D3Z3V3
      Related
      ENSMUSP00000101920.1, OTTMUSP00000025011, ENSMUST00000106313.7, OTTMUST00000052671
      Conserved Domains (1) summary
      pfam00735
      Location:1267
      Septin; Septin
    5. XM_006508032.1XP_006508095.1  septin-1 isoform X4

      Conserved Domains (1) summary
      cl21455
      Location:11119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. XM_011241863.1XP_011240165.1  septin-1 isoform X3

      Conserved Domains (1) summary
      cl21455
      Location:22296
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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