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    Nell2 NEL-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 54003, updated on 11-Apr-2024

    Summary

    Official Symbol
    Nell2provided by MGI
    Official Full Name
    NEL-like 2provided by MGI
    Primary source
    MGI:MGI:1858510
    See related
    Ensembl:ENSMUSG00000022454 AllianceGenome:MGI:1858510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mel91; A330108N19Rik
    Summary
    Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Predicted to be located in several cellular components, including dendrite; extracellular space; and perikaryon. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 60.0), frontal lobe adult (RPKM 49.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    15 E3; 15 49.39 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (95117321..95426677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (95219440..95528796, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100043315 Neighboring gene STARR-seq mESC enhancer starr_39563 Neighboring gene predicted gene, 31075 Neighboring gene STARR-seq mESC enhancer starr_39564 Neighboring gene predicted gene, 31370 Neighboring gene STARR-seq mESC enhancer starr_39565 Neighboring gene STARR-seq mESC enhancer starr_39566 Neighboring gene STARR-seq mESC enhancer starr_39567 Neighboring gene STARR-seq mESC enhancer starr_39568 Neighboring gene predicted gene, 31551 Neighboring gene predicted gene, 24668

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in commissural neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in development of secondary female sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C-binding protein NELL2
    Names
    NEL-like protein 2
    nel-like 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289653.1NP_001276582.1  protein kinase C-binding protein NELL2 precursor

      See identical proteins and their annotated locations for NP_001276582.1

      Status: VALIDATED

      Source sequence(s)
      AC109198, AC163991, AC164402
      Consensus CDS
      CCDS27775.1
      UniProtKB/Swiss-Prot
      Q61220, Q80UM5
      UniProtKB/TrEMBL
      A0A2R8VHV8
      Related
      ENSMUSP00000074751.3, ENSMUST00000075275.3
      Conserved Domains (5) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain
    2. NM_001356950.1NP_001343879.1  protein kinase C-binding protein NELL2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC109198, AC163991, AC164402
      Consensus CDS
      CCDS27775.1
      UniProtKB/Swiss-Prot
      Q61220, Q80UM5
      UniProtKB/TrEMBL
      A0A2R8VHV8
      Related
      ENSMUSP00000131665.2, ENSMUST00000166170.9
      Conserved Domains (5) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain
    3. NM_001356951.1NP_001343880.1  protein kinase C-binding protein NELL2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC109198, AC163991, AC164402
      Consensus CDS
      CCDS27775.1
      UniProtKB/Swiss-Prot
      Q61220, Q80UM5
      UniProtKB/TrEMBL
      A0A2R8VHV8
      Related
      ENSMUSP00000155490.2, ENSMUST00000229981.2
      Conserved Domains (5) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      95117321..95426677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521163.3XP_006521226.1  protein kinase C-binding protein NELL2 isoform X1

      See identical proteins and their annotated locations for XP_006521226.1

      UniProtKB/Swiss-Prot
      Q61220, Q80UM5
      UniProtKB/TrEMBL
      A0A2R8VHV8
      Conserved Domains (5) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain
    2. XM_036159519.1XP_036015412.1  protein kinase C-binding protein NELL2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8VHV8
      Conserved Domains (6) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam00093
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:708758
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain
    3. XM_006521164.5XP_006521227.1  protein kinase C-binding protein NELL2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8VHV8
      Related
      ENSMUSP00000155436.2, ENSMUST00000229933.2
      Conserved Domains (6) summary
      smart00179
      Location:558592
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:32217
      TSPN; Thrombospondin N-terminal -like domains
      pfam00093
      Location:277333
      VWC; von Willebrand factor type C domain
      pfam07645
      Location:605636
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:708758
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:489524
      EGF_3; EGF domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016743.2: Suppressed sequence

      Description
      NM_016743.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.