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    IL20RA interleukin 20 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 53832, updated on 17-Jun-2019

    Summary

    Official Symbol
    IL20RAprovided by HGNC
    Official Full Name
    interleukin 20 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:6003
    See related
    Ensembl:ENSG00000016402 MIM:605620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
    Summary
    This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in skin (RPKM 13.8), adrenal (RPKM 3.9) and 13 other tissues See more
    Orthologs

    Genomic context

    See IL20RA in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (136999971..137045180, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137321108..137366317, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 3 Neighboring gene neuroblastoma highly expressed 1 Neighboring gene interleukin 22 receptor subunit alpha 2 Neighboring gene interferon gamma receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
      Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ40993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-20 receptor subunit alpha
    Names
    class II cytokine receptor ZCYTOR7
    cytokine receptor family 2 member 8
    interleukin 20 receptor alpha subunit
    interleukin 20 receptor, alpha
    interleukin-20 receptor I

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278722.1NP_001265651.1  interleukin-20 receptor subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK297121, AL135902, BC113574, HY009306
      Consensus CDS
      CCDS64536.1
      UniProtKB/Swiss-Prot
      Q9UHF4
      Related
      ENSP00000437843.1, ENST00000541547.5
      Conserved Domains (2) summary
      pfam01108
      Location:174
      Tissue_fac; Tissue factor
      pfam09294
      Location:86190
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    2. NM_001278723.1NP_001265652.1  interleukin-20 receptor subunit alpha isoform 3

      See identical proteins and their annotated locations for NP_001265652.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL135902, AY358883, DN998331
      Consensus CDS
      CCDS64535.1
      UniProtKB/Swiss-Prot
      Q9UHF4
      Related
      ENSP00000356722.1, ENST00000367748.4
      Conserved Domains (1) summary
      pfam09294
      Location:25128
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    3. NM_001278724.2NP_001265653.2  interleukin-20 receptor subunit alpha isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL135902
    4. NM_014432.3NP_055247.3  interleukin-20 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_055247.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL135902, BC113574, DN998331
      Consensus CDS
      CCDS5181.1
      UniProtKB/Swiss-Prot
      Q9UHF4
      Related
      ENSP00000314976.5, ENST00000316649.9
      Conserved Domains (2) summary
      pfam01108
      Location:32123
      Tissue_fac; Tissue factor
      pfam09294
      Location:135239
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      136999971..137045180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010954.2XP_016866443.1  interleukin-20 receptor subunit alpha isoform X1

    2. XM_011535904.2XP_011534206.1  interleukin-20 receptor subunit alpha isoform X3

      UniProtKB/Swiss-Prot
      Q9UHF4
      Conserved Domains (1) summary
      pfam09294
      Location:25128
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    3. XM_017010955.1XP_016866444.1  interleukin-20 receptor subunit alpha isoform X2

    4. XM_006715506.2XP_006715569.1  interleukin-20 receptor subunit alpha isoform X4

      Conserved Domains (1) summary
      pfam09294
      Location:21106
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
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