U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PLK1 polo like kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5347, updated on 11-Apr-2024

    Summary

    Official Symbol
    PLK1provided by HGNC
    Official Full Name
    polo like kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:9077
    See related
    Ensembl:ENSG00000166851 MIM:602098; AllianceGenome:HGNC:9077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLK; STPK13
    Summary
    The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in testis (RPKM 20.5), lymph node (RPKM 15.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    16p12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (23678889..23690367)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23954691..23966171)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23690210..23701688)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:23651698-23651932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23653060-23653849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10585 Neighboring gene partner and localizer of BRCA2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23698309-23698810 Neighboring gene dynactin subunit 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23716303-23716803 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:23740522-23741453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23766235-23766880 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:23797941-23798576 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:23798577-23799212 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1865 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1866 Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23846913-23847460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23847461-23848006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10590 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:23858657-23858875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10591 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:23877081-23877727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10592 Neighboring gene protein kinase C beta Neighboring gene GATA motif-containing MPRA enhancer 73 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:23915426-23915611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10598 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24066265-24066934 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:24086836-24087648 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:24087649-24088461 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:24119013-24119512 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24146937-24147472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:24148009-24148544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:24148545-24149080 Neighboring gene Sharpr-MPRA regulatory region 8464 Neighboring gene microRNA 1273h

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of polo-like kinase 1 (PLK1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PLK1 PubMed
    Tat tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
    tat HIV-1 Tat directly interacts with Plk1 through the kinase (residues 53-305) and the polo-box (residues 417-480) domains of Plk1 PubMed
    Vpr vpr HIV-1 Vpr R80A mutant demonstrates decreased or absent TNF production from MT4C5 cells suggesting that PLK1-Vpr interaction affects TNF production from HIV-1 infected cells PubMed
    vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein polo-like kinase 1 (PLK1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables magnesium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    involved_in Golgi inheritance TAS
    Traceable Author Statement
    more info
     
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via alternative nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female meiosis chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homologous chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase/anaphase transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic chromosome condensation TAS
    Traceable Author Statement
    more info
     
    involved_in mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cytokinesis TAS
    Traceable Author Statement
    more info
     
    involved_in mitotic nuclear membrane disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle organization TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear membrane disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to nucleus TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle phase transition TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    involved_in synaptonemal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PLK1
    Names
    PLK-1
    cell cycle regulated protein kinase
    polo (Drosophia)-like kinase
    serine/threonine-protein kinase 13
    NP_005021.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005030.6NP_005021.2  serine/threonine-protein kinase PLK1

      See identical proteins and their annotated locations for NP_005021.2

      Status: REVIEWED

      Source sequence(s)
      BC014846, DC300189
      Consensus CDS
      CCDS10616.1
      UniProtKB/Swiss-Prot
      P53350, Q15153, Q99746
      UniProtKB/TrEMBL
      B2R841
      Related
      ENSP00000300093.4, ENST00000300093.9
      Conserved Domains (3) summary
      cd13117
      Location:509590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14187
      Location:45309
      STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      23678889..23690367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      23954691..23966171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)