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    PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Homo sapiens (human) ]

    Gene ID: 5290, updated on 12-Nov-2024

    Summary

    Official Symbol
    PIK3CAprovided by HGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:8975
    See related
    Ensembl:ENSG00000121879 MIM:171834; AllianceGenome:HGNC:8975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMH; MCM; CCM4; CWS5; MCAP; PI3K; CLAPO; CLOVE; MCMTC; PI3K-alpha; p110-alpha
    Summary
    Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in fat (RPKM 10.3), gall bladder (RPKM 7.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIK3CA in Genome Data Viewer
    Location:
    3q26.32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (179148126..179240093)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (181951917..182043930)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (178866145..178957881)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20858 Neighboring gene zinc finger matrin-type 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20859 Neighboring gene PIK3CA divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:178866509-178867008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14912 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14913 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:178905170-178905394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:178980593-178981094 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene LRR binding FLII interacting protein 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:179008749-179009491 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20865 Neighboring gene zinc finger protein 639

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cerebral cavernous malformation 4 not available
    CLAPO syndrome not available
    CLOVES syndrome not available
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    not available
    Congenital macrodactylia not available
    Cowden syndrome 5 not available
    Epidermal nevus not available
    Familial cancer of breast not available
    Gastric cancer
    MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
    not available
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    not available
    Lung cancer
    MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
    not available
    Megalencephaly-capillary malformation-polymicrogyria syndrome not available
    Ovarian neoplasm
    MedGen: C0919267 GeneReviews: Not available
    not available
    Seborrheic keratosis
    MedGen: C0022603 OMIM: 182000 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2015-03-12)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2015-03-12)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
    env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
    Nef nef HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively PubMed
    nef HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes PubMed
    nef HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression PubMed
    nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
    nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
    nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
    nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
    Tat tat HIV-1 Tat and cocaine treatment activates PI3K and AKT in human pulmonary arterial smooth muscle cells PubMed
    tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
    tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
    tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
    tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
    tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
    tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
    tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
    tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
    Vpr vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes PubMed
    vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC142161, MGC142163

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell costimulation TAS
    Traceable Author Statement
    more info
     
    involved_in T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anoikis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in autosome genomic imprinting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrostatic pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of anoikis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macroautophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of TOR signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein localization to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular respiration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to butyrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to dexamethasone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle inactivity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle stretch ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vasculature development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of phosphatidylinositol 3-kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    PI3-kinase p110 subunit alpha
    mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
    phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
    phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphoinositide 3-kinase alpha
    phosphoinositide-3-kinase, catalytic, alpha polypeptide
    ptdIns-3-kinase subunit p110-alpha
    serine/threonine protein kinase PIK3CA
    NP_006209.2
    XP_006713721.1
    XP_054202817.1
    XP_054202818.1
    XP_054202819.1
    XP_054202820.1
    XP_054202821.1
    XP_054202822.1
    XP_054202823.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012113.2 RefSeqGene

      Range
      5001..91190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_310

    mRNA and Protein(s)

    1. NM_006218.4NP_006209.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_006209.2

      Status: REVIEWED

      Source sequence(s)
      AC076966, AI379480, AU129890, AW445128, BQ228953, BX437219, BX473473, BX484734, U79143
      Consensus CDS
      CCDS43171.1
      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
      UniProtKB/TrEMBL
      Q4LE51
      Related
      ENSP00000263967.3, ENST00000263967.4
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      179148126..179240093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713658.5XP_006713721.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      See identical proteins and their annotated locations for XP_006713721.1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
      UniProtKB/TrEMBL
      Q4LE51
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      181951917..182043930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346842.1XP_054202817.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    2. XM_054346845.1XP_054202820.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    3. XM_054346848.1XP_054202823.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    4. XM_054346846.1XP_054202821.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    5. XM_054346844.1XP_054202819.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    6. XM_054346847.1XP_054202822.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762
    7. XM_054346843.1XP_054202818.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P42336, Q14CW1, Q99762