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    CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ]

    Gene ID: 51755, updated on 17-Jun-2019

    Summary

    Official Symbol
    CDK12provided by HGNC
    Official Full Name
    cyclin dependent kinase 12provided by HGNC
    Primary source
    HGNC:HGNC:24224
    See related
    Ensembl:ENSG00000167258 MIM:615514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRK7; CRKR; CRKRS
    Expression
    Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See CDK12 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39461486..39567560)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37617739..37721398)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 20 Neighboring gene microRNA 548BC Neighboring gene mediator complex subunit 1 Neighboring gene RNA, U6 small nuclear 233, pseudogene Neighboring gene uncharacterized LOC105371770 Neighboring gene uncharacterized LOC105371771

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • TP53 Regulates Transcription of DNA Repair Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of DNA Repair Genes, organism-specific biosystemSeveral DNA repair genes contain p53 response elements and their transcription is positively regulated by TP53 (p53). TP53-mediated regulation probably ensures increased protein level of DNA repair g...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0904

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation of RNA polymerase II C-terminal domain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin K-CDK12 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 12
    Names
    CDC2-related protein kinase 7
    Cdc2-related kinase, arginine/serine-rich
    cell division cycle 2-related protein kinase 7
    cell division protein kinase 12
    NP_055898.1
    NP_057591.2
    XP_005257513.1
    XP_005257515.1
    XP_011523194.1
    XP_011523195.1
    XP_011523196.1
    XP_011523197.1
    XP_011523198.1
    XP_011523199.1
    XP_011523200.1
    XP_011523201.1
    XP_011523202.1
    XP_011523203.1
    XP_011523204.1
    XP_011523205.1
    XP_011523207.1
    XP_011523208.1
    XP_011523209.1
    XP_016880236.1
    XP_016880237.1
    XP_016880238.1
    XP_016880239.1
    XP_016880240.1
    XP_016880241.1
    XP_016880242.1
    XP_024306569.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065324.1 RefSeqGene

      Range
      5001..78059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015083.3NP_055898.1  cyclin-dependent kinase 12 isoform 2

      See identical proteins and their annotated locations for NP_055898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC009283, AK302645, BC150265, BE003756, BM557102
      Consensus CDS
      CCDS45666.1
      UniProtKB/Swiss-Prot
      Q9NYV4
      Related
      ENSP00000407720.2, ENST00000430627.6
      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. NM_016507.4NP_057591.2  cyclin-dependent kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_057591.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC009283, AF227198, AK302645, BC150265, BE003756, BM557102
      Consensus CDS
      CCDS11337.1
      UniProtKB/Swiss-Prot
      Q9NYV4
      Related
      ENSP00000398880.3, ENST00000447079.4
      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      39461486..39567560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524896.2XP_011523198.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523198.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. XM_011524897.2XP_011523199.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523199.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    3. XM_024450801.1XP_024306569.1  cyclin-dependent kinase 12 isoform X3

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    4. XM_011524895.2XP_011523197.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523197.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    5. XM_011524893.2XP_011523195.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523195.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    6. XM_011524894.2XP_011523196.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523196.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    7. XM_011524903.2XP_011523205.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523205.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    8. XM_011524901.2XP_011523203.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523203.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    9. XM_017024748.1XP_016880237.1  cyclin-dependent kinase 12 isoform X3

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    10. XM_011524900.2XP_011523202.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523202.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    11. XM_017024747.1XP_016880236.1  cyclin-dependent kinase 12 isoform X3

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    12. XM_011524899.2XP_011523201.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523201.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    13. XM_011524898.2XP_011523200.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523200.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    14. XM_017024749.1XP_016880238.1  cyclin-dependent kinase 12 isoform X3

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    15. XM_011524902.2XP_011523204.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523204.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    16. XM_017024752.1XP_016880241.1  cyclin-dependent kinase 12 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    17. XM_017024750.1XP_016880239.1  cyclin-dependent kinase 12 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    18. XM_017024751.1XP_016880240.1  cyclin-dependent kinase 12 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    19. XM_011524907.2XP_011523209.1  cyclin-dependent kinase 12 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    20. XM_011524905.2XP_011523207.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523207.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    21. XM_011524906.2XP_011523208.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523208.1

      Conserved Domains (1) summary
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    22. XM_011524892.2XP_011523194.1  cyclin-dependent kinase 12 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:727994
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:719994
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    23. XM_005257458.4XP_005257515.1  cyclin-dependent kinase 12 isoform X6

      Related
      ENSP00000464641.1, ENST00000584632.5
      Conserved Domains (2) summary
      smart00220
      Location:7271020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7191020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    24. XM_017024753.2XP_016880242.1  cyclin-dependent kinase 12 isoform X5

    25. XM_005257456.4XP_005257513.1  cyclin-dependent kinase 12 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:7261019
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7181019
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
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