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    SARAF store-operated calcium entry associated regulatory factor [ Homo sapiens (human) ]

    Gene ID: 51669, updated on 17-Jun-2019

    Summary

    Official Symbol
    SARAFprovided by HGNC
    Official Full Name
    store-operated calcium entry associated regulatory factorprovided by HGNC
    Primary source
    HGNC:HGNC:28789
    See related
    Ensembl:ENSG00000133872 MIM:614768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XTP3; FOAP-7; TMEM66; HSPC035
    Expression
    Ubiquitous expression in brain (RPKM 148.3), adrenal (RPKM 121.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See SARAF in Genome Data Viewer
    Location:
    8p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30063003..30083208, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29920609..29940649, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1218, pseudogene Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of transmembrane protein 66 (TMEM66) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8721, FLJ22274

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of store-operated calcium entry IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    store-operated calcium entry-associated regulatory factor
    Names
    HBV X-transactivated gene 3 protein
    HBV XAg-transactivated protein 3
    SARAF long isoform
    SARAF short isoform
    SOCE-associated regulatory factor
    testicular secretory protein Li 59
    transmembrane protein 66

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284239.1NP_001271168.1  store-operated calcium entry-associated regulatory factor isoform 2

      See identical proteins and their annotated locations for NP_001271168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC044849, AK315956, BM280420, DC359554
      Consensus CDS
      CCDS64866.1
      UniProtKB/Swiss-Prot
      Q96BY9
      Related
      ENSP00000441351.1, ENST00000545648.2
      Conserved Domains (1) summary
      pfam06682
      Location:2167
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis
    2. NM_016127.6NP_057211.4  store-operated calcium entry-associated regulatory factor isoform 1 precursor

      See identical proteins and their annotated locations for NP_057211.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC044849
      Consensus CDS
      CCDS6074.1
      UniProtKB/Swiss-Prot
      Q96BY9
      UniProtKB/TrEMBL
      A0A140VK59
      Related
      ENSP00000256255.6, ENST00000256255.10
      Conserved Domains (1) summary
      pfam06682
      Location:24339
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      30063003..30083208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013569.1XP_016869058.1  store-operated calcium entry-associated regulatory factor isoform X3

      UniProtKB/TrEMBL
      B7Z307
      Conserved Domains (1) summary
      pfam06682
      Location:2303
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis
    2. XM_017013570.2XP_016869059.1  store-operated calcium entry-associated regulatory factor isoform X4

      Related
      ENSP00000427769.1, ENST00000518296.5
    3. XM_017013567.2XP_016869056.1  store-operated calcium entry-associated regulatory factor isoform X1

    4. XM_017013568.1XP_016869057.1  store-operated calcium entry-associated regulatory factor isoform X2

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