Format

Send to:

Choose Destination
    • Showing Current items.

    NUB1 negative regulator of ubiquitin like proteins 1 [ Homo sapiens (human) ]

    Gene ID: 51667, updated on 17-Jul-2021

    Summary

    Official Symbol
    NUB1provided by HGNC
    Official Full Name
    negative regulator of ubiquitin like proteins 1provided by HGNC
    Primary source
    HGNC:HGNC:17623
    See related
    Ensembl:ENSG00000013374 MIM:607981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BS4; NUB1L; NYREN18
    Summary
    This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in lymph node (RPKM 24.3), testis (RPKM 24.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NUB1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151341699..151378449)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151038898..151075535)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene microRNA 671 Neighboring gene WD repeat domain 86 Neighboring gene WDR86 antisense RNA 1 Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular negative regulator of ubiquitin-like protein 1 (NUB1) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    NEDD8 ultimate buster 1
    Names
    NEDD8 ultimate buster-1
    renal carcinoma antigen NY-REN-18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029746.2 RefSeqGene

      Range
      5001..41701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243351.2NP_001230280.2  NEDD8 ultimate buster 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2, also known as NUB1L).
      Source sequence(s)
      AC005486
      Consensus CDS
      CCDS59089.1
      Related
      ENSP00000454264.2, ENST00000568733.6
      Conserved Domains (4) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:435468
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:493528
      UBA_like_SF; UBA domain-like superfamily
    2. NM_001363529.2NP_001350458.1  NEDD8 ultimate buster 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Consensus CDS
      CCDS87565.1
      Related
      ENSP00000418234.2, ENST00000470229.6
      Conserved Domains (4) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:435468
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:493528
      UBA_like_SF; UBA domain-like superfamily
    3. NM_001385353.1NP_001372282.1  NEDD8 ultimate buster 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Conserved Domains (3) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:479514
      UBA_like_SF; UBA domain-like superfamily
    4. NM_001385354.1NP_001372283.1  NEDD8 ultimate buster 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Conserved Domains (3) summary
      cd14291
      Location:375410
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:478513
      UBA_like_SF; UBA domain-like superfamily
    5. NM_001385355.1NP_001372284.1  NEDD8 ultimate buster 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Conserved Domains (3) summary
      cd14291
      Location:375410
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:478513
      UBA_like_SF; UBA domain-like superfamily
    6. NM_001385356.1NP_001372285.1  NEDD8 ultimate buster 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Conserved Domains (3) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:444479
      UBA_like_SF; UBA domain-like superfamily
    7. NM_001385361.1NP_001372290.1  NEDD8 ultimate buster 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC005486
      Conserved Domains (3) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:444479
      UBA_like_SF; UBA domain-like superfamily
    8. NM_016118.5NP_057202.4  NEDD8 ultimate buster 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2, also known as NUB1) that is shorter than isoform 1.
      Source sequence(s)
      AC005486
      Consensus CDS
      CCDS47751.2
      Related
      ENSP00000398644.3, ENST00000413040.7
      Conserved Domains (3) summary
      cd14291
      Location:376411
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      pfam18037
      Location:70163
      Ubiquitin_5; Ubiquitin-like domain
      cl21463
      Location:479514
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      151341699..151378449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012304.1XP_016867793.1  NEDD8 ultimate buster 1 isoform X1

    2. XM_017012308.1XP_016867797.1  NEDD8 ultimate buster 1 isoform X7

    3. XM_024446798.1XP_024302566.1  NEDD8 ultimate buster 1 isoform X9

      Conserved Domains (3) summary
      cd14291
      Location:223258
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:282315
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:340375
      UBA_like_SF; UBA domain-like superfamily
    4. XM_024446799.1XP_024302567.1  NEDD8 ultimate buster 1 isoform X10

      Conserved Domains (2) summary
      cd14291
      Location:223258
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:326361
      UBA_like_SF; UBA domain-like superfamily
    Support Center