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    FKBP7 FKBP prolyl isomerase 7 [ Homo sapiens (human) ]

    Gene ID: 51661, updated on 3-Dec-2023

    Summary

    Official Symbol
    FKBP7provided by HGNC
    Official Full Name
    FKBP prolyl isomerase 7provided by HGNC
    Primary source
    HGNC:HGNC:3723
    See related
    Ensembl:ENSG00000079150 MIM:607062; AllianceGenome:HGNC:3723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKBP23; PPIase
    Summary
    The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 13.6), endometrium (RPKM 9.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FKBP7 in Genome Data Viewer
    Location:
    2q31.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (178463664..178478600, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (178946457..178961394, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179328391..179343327, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cholesterol induced regulator of metabolism RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:179315058-179315632 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene uncharacterized LOC124906102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12150 Neighboring gene uncharacterized LOC124907911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16805 Neighboring gene nuclear distribution C pseudogene 2 Neighboring gene pejvakin Neighboring gene pleckstrin homology domain containing A3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12151 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:179387607-179388119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16810 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179401104-179402303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16811 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179407630-179408829 Neighboring gene TTN antisense RNA 1 Neighboring gene titin Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179440205-179441404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179443309-179444508 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179456337-179457536 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179471933-179473132 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179478848-179480047

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9420

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FK506 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP7
    Names
    23 kDa FK506-binding protein
    23 kDa FKBP
    FK506 binding protein 7
    FK506-binding protein 23
    FKBP-23
    FKBP-7
    PPIase FKBP7
    rotamase
    NP_001128684.1
    NP_001397901.1
    NP_851939.1
    XP_011509650.1
    XP_011509651.1
    XP_054198524.1
    XP_054198525.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135212.2NP_001128684.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform b precursor

      See identical proteins and their annotated locations for NP_001128684.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is 1 amino acid shorter than isoform a.
      Source sequence(s)
      AA447628, AC009948, AY353086, BC009711, DA020387
      Consensus CDS
      CCDS46462.1
      UniProtKB/Swiss-Prot
      Q9Y680
      Related
      ENSP00000415486.2, ENST00000434643.6
      Conserved Domains (3) summary
      pfam00254
      Location:46140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:151213
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:151212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_001410972.1NP_001397901.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC009948, AK299215
      Consensus CDS
      CCDS92911.1
      UniProtKB/TrEMBL
      B4DRE2
      Related
      ENSP00000509396.1, ENST00000464248.1
    3. NM_181342.3NP_851939.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform a precursor

      See identical proteins and their annotated locations for NP_851939.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA447628, AC009948, BC009711, DA020387
      Consensus CDS
      CCDS2280.1
      UniProtKB/Swiss-Prot
      Q4ZG70, Q6V3B2, Q86U65, Q96DA4, Q9Y680, Q9Y6B0
      Related
      ENSP00000413152.2, ENST00000424785.7
      Conserved Domains (2) summary
      pfam00254
      Location:46141
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:152214
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      178463664..178478600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511349.4XP_011509651.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

      Conserved Domains (3) summary
      pfam13499
      Location:44106
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:44105
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19519
      Location:1733
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    2. XM_011511348.4XP_011509650.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

      Conserved Domains (3) summary
      pfam13499
      Location:45107
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:45106
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl19519
      Location:1734
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RNA

    1. XR_007076405.1 RNA Sequence

    2. XR_007076404.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      178946457..178961394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342550.1XP_054198525.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

    2. XM_054342549.1XP_054198524.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

    RNA

    1. XR_008486417.1 RNA Sequence

    2. XR_008486416.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016105.2: Suppressed sequence

      Description
      NM_016105.2: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a valid protein.