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    UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) [ Homo sapiens (human) ]

    Gene ID: 51619, updated on 7-Apr-2024

    Summary

    Official Symbol
    UBE2D4provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 D4 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:21647
    See related
    Ensembl:ENSG00000078967 AllianceGenome:HGNC:21647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBUCE1
    Summary
    Enables ubiquitin conjugating enzyme activity. Involved in protein polyubiquitination. Acts upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 5.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    7p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (43926436..43956136)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44084736..44114438)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43966035..43995735)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene URGCP-MRPS24 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18130 Neighboring gene uncharacterized LOC124901620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25921 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:43911515-43911690 Neighboring gene upregulator of cell proliferation Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18133 Neighboring gene tubulin gamma 1 pseudogene Neighboring gene RNA polymerase II subunit J4 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44010479-44010996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18136 Neighboring gene speedy/RINGO cell cycle regulator family member E1 Neighboring gene Sharpr-MPRA regulatory region 7454 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44070666-44070855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44075983-44076482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18138 Neighboring gene RAS p21 protein activator 4C, pseudogene Neighboring gene long intergenic non-protein coding RNA 957

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 D4
    Names
    E2 ubiquitin-conjugating enzyme D4
    ubiquitin carrier protein D4
    ubiquitin conjugating enzyme E2D 4 (putative)
    ubiquitin-conjugating enzyme HBUCE1
    ubiquitin-protein ligase D4
    NP_057067.1
    XP_006715797.1
    XP_024302563.1
    XP_047276417.1
    XP_047276418.1
    XP_047276419.1
    XP_047276420.1
    XP_054214351.1
    XP_054214352.1
    XP_054214353.1
    XP_054214354.1
    XP_054214355.1
    XP_054214356.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015983.4NP_057067.1  ubiquitin-conjugating enzyme E2 D4

      See identical proteins and their annotated locations for NP_057067.1

      Status: VALIDATED

      Source sequence(s)
      AC004985, AW014299, BC004104, BG499454
      Consensus CDS
      CCDS5474.1
      UniProtKB/Swiss-Prot
      A4D1V0, Q9Y2X8
      Related
      ENSP00000222402.2, ENST00000222402.8
      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      43926436..43956136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715734.4XP_006715797.1  ubiquitin-conjugating enzyme E2 D4 isoform X2

      Conserved Domains (1) summary
      cl00154
      Location:1146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_047420461.1XP_047276417.1  ubiquitin-conjugating enzyme E2 D4 isoform X3

    3. XM_047420462.1XP_047276418.1  ubiquitin-conjugating enzyme E2 D4 isoform X4

    4. XM_047420463.1XP_047276419.1  ubiquitin-conjugating enzyme E2 D4 isoform X5

    5. XM_024446795.2XP_024302563.1  ubiquitin-conjugating enzyme E2 D4 isoform X1

      Conserved Domains (1) summary
      cl00154
      Location:54191
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    6. XM_047420464.1XP_047276420.1  ubiquitin-conjugating enzyme E2 D4 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      44084736..44114438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358378.1XP_054214353.1  ubiquitin-conjugating enzyme E2 D4 isoform X3

    2. XM_054358379.1XP_054214354.1  ubiquitin-conjugating enzyme E2 D4 isoform X4

    3. XM_054358377.1XP_054214352.1  ubiquitin-conjugating enzyme E2 D4 isoform X2

    4. XM_054358380.1XP_054214355.1  ubiquitin-conjugating enzyme E2 D4 isoform X5

    5. XM_054358376.1XP_054214351.1  ubiquitin-conjugating enzyme E2 D4 isoform X1

    6. XM_054358381.1XP_054214356.1  ubiquitin-conjugating enzyme E2 D4 isoform X6