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    NSG2 neuronal vesicle trafficking associated 2 [ Homo sapiens (human) ]

    Gene ID: 51617, updated on 11-Apr-2024

    Summary

    Official Symbol
    NSG2provided by HGNC
    Official Full Name
    neuronal vesicle trafficking associated 2provided by HGNC
    Primary source
    HGNC:HGNC:24955
    See related
    Ensembl:ENSG00000170091 MIM:616752; AllianceGenome:HGNC:24955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALY3; HMP19
    Summary
    Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly and endosomal transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 115.2) and adrenal (RPKM 19.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    5q35.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (174045706..174109179)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (174586043..174649463)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (173472709..173536182)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:173446513-173447102 Neighboring gene chromosome 5 open reading frame 47 Neighboring gene ribosomal protein L12 pseudogene 22 Neighboring gene uncharacterized LOC102724551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173517875-173518376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173518377-173518876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173571770-173572270 Neighboring gene MPRA-validated peak5582 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173586113-173586614 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173630390-173630890 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173632590-173633351 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:173631827-173632589 Neighboring gene uncharacterized LOC124901139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173734378-173734878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173754289-173754790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173754791-173755290 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:173755250-173756449 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:173762765-173763964 Neighboring gene long intergenic non-protein coding RNA 1411 Neighboring gene cysteine rich transmembrane module containing 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi cis cisterna membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in multivesicular body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    neuronal vesicle trafficking-associated protein 2
    Names
    calcyon family member 3
    hypothalamus golgi apparatus expressed 19 kDa protein
    neuron-specific protein family member 2
    p19 protein
    protein p19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015980.5NP_057064.1  neuronal vesicle trafficking-associated protein 2

      See identical proteins and their annotated locations for NP_057064.1

      Status: VALIDATED

      Source sequence(s)
      BC002619, CD627354, DC366641, EL950772
      Consensus CDS
      CCDS4391.1
      UniProtKB/Swiss-Prot
      B2R5Y0, D3DQN0, Q9UHX8, Q9Y328
      UniProtKB/TrEMBL
      Q6IAL2
      Related
      ENSP00000307722.3, ENST00000303177.8
      Conserved Domains (1) summary
      pfam06387
      Location:1166
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      174045706..174109179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      174586043..174649463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)