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    LSR lipolysis stimulated lipoprotein receptor [ Homo sapiens (human) ]

    Gene ID: 51599, updated on 15-Jun-2019

    Summary

    Official Symbol
    LSRprovided by HGNC
    Official Full Name
    lipolysis stimulated lipoprotein receptorprovided by HGNC
    Primary source
    HGNC:HGNC:29572
    See related
    Ensembl:ENSG00000105699 MIM:616582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILDR3; LISCH7
    Expression
    Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See LSR in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (35248656..35267964)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35739290..35758867)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187 member B Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene uncharacterized LOC105372380 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene HNF4 motif-containing MPRA enhancer 344

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • LDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      LDL-mediated lipid transport, organism-specific biosystemLDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipid...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • VLDL interactions, organism-specific biosystem (from REACTOME)
      VLDL interactions, organism-specific biosystemVery-low-density lipoprotein (VLDL) is a lipoprotein made by the liver (Gibbons et al. 2004) and is one of the five major groups of lipoproteins (chylomicrons, VLDL, LDL, IDL and HDL) that enable fat...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC10659, MGC48312, MGC48503

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    establishment of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    tricellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chylomicron IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tricellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lipolysis-stimulated lipoprotein receptor
    Names
    LISCH protein
    immunoglobulin-like domain containing receptor 3
    lipolysis-stimulated remnant
    liver-specific bHLH-Zip transcription factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260489.1NP_001247418.1  lipolysis-stimulated lipoprotein receptor isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK126834, BM837160, BM971691, CF141732
      Consensus CDS
      CCDS59376.1
      UniProtKB/Swiss-Prot
      Q86X29
      Related
      ENSP00000472569.1, ENST00000602122.5
      Conserved Domains (1) summary
      pfam08648
      Location:490587
      DUF1777; Protein of unknown function (DUF1777)
    2. NM_001260490.1NP_001247419.1  lipolysis-stimulated lipoprotein receptor isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK126834, AK296618, BM837160, BM971691
      UniProtKB/Swiss-Prot
      Q86X29
      Related
      ENSP00000394479.1, ENST00000427250.5
      Conserved Domains (2) summary
      PHA03307
      Location:202498
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR01622
      Location:419533
      SF-CC1; splicing factor, CC1-like family
    3. NM_015925.6NP_057009.3  lipolysis-stimulated lipoprotein receptor isoform 1

      See identical proteins and their annotated locations for NP_057009.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK126834, BC004381, BM837160, BM971691
      Consensus CDS
      CCDS12449.1
      UniProtKB/Swiss-Prot
      Q86X29
      Related
      ENSP00000346976.2, ENST00000354900.7
      Conserved Domains (1) summary
      pfam08648
      Location:491588
      DUF1777; Protein of unknown function (DUF1777)
    4. NM_205834.3NP_991403.1  lipolysis-stimulated lipoprotein receptor isoform 2

      See identical proteins and their annotated locations for NP_991403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AK126834, BC047376, BM971691
      Consensus CDS
      CCDS12450.1
      UniProtKB/Swiss-Prot
      Q86X29
      Related
      ENSP00000480821.1, ENST00000621372.4
      Conserved Domains (1) summary
      cl28033
      Location:310606
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    5. NM_205835.3NP_991404.1  lipolysis-stimulated lipoprotein receptor isoform 3

      See identical proteins and their annotated locations for NP_991404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK126834, AK130367, BM837160, BM971691
      Consensus CDS
      CCDS12451.1
      UniProtKB/Swiss-Prot
      Q86X29
      Related
      ENSP00000354034.2, ENST00000360798.7
      Conserved Domains (1) summary
      pfam08648
      Location:442539
      DUF1777; Protein of unknown function (DUF1777)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      35248656..35267964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258980.2XP_005259037.1  lipolysis-stimulated lipoprotein receptor isoform X1

      Related
      ENSP00000262627.3, ENST00000347609.8
      Conserved Domains (1) summary
      pfam08648
      Location:509606
      DUF1777; Protein of unknown function (DUF1777)
    2. XM_011527026.2XP_011525328.1  lipolysis-stimulated lipoprotein receptor isoform X2

      Conserved Domains (1) summary
      pfam08648
      Location:461558
      DUF1777; Protein of unknown function (DUF1777)
    3. XM_005258982.2XP_005259039.1  lipolysis-stimulated lipoprotein receptor isoform X3

      Conserved Domains (1) summary
      PHA03307
      Location:242537
      PHA03307; transcriptional regulator ICP4; Provisional
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