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    HDAC7 histone deacetylase 7 [ Homo sapiens (human) ]

    Gene ID: 51564, updated on 8-Dec-2022

    Summary

    Official Symbol
    HDAC7provided by HGNC
    Official Full Name
    histone deacetylase 7provided by HGNC
    Primary source
    HGNC:HGNC:14067
    See related
    Ensembl:ENSG00000061273 MIM:606542; AllianceGenome:HGNC:14067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD7; HD7A; HDAC7A
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 18.9), spleen (RPKM 18.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HDAC7 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (47782722..47821344, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (47744115..47781298, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48176505..48213686, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RPAP3 divergent transcript Neighboring gene endonuclease, poly(U) specific Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene Sharpr-MPRA regulatory region 8178 Neighboring gene solute carrier family 48 member 1 Neighboring gene uncharacterized LOC124902926 Neighboring gene long intergenic non-protein coding RNA 2354 Neighboring gene vitamin D receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA downregulates HDAC7 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ99588, DKFZp586J0917

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SUMO transferase activity TAS
    Traceable Author Statement
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone deacetylase 7
    Names
    histone deacetylase 7A
    NP_001091886.1
    NP_001295019.1
    NP_001354975.1
    NP_056216.2
    XP_011536782.1
    XP_011536783.2
    XP_011536785.1
    XP_024304786.1
    XP_047284934.1
    XP_047284935.1
    XP_047284936.1
    XP_047284937.1
    XP_047284938.1
    XP_047284939.1
    XP_047284940.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098416.4NP_001091886.1  histone deacetylase 7 isoform d

      See identical proteins and their annotated locations for NP_001091886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter than isoform a.
      Source sequence(s)
      BC020505, BC064840, DC376749
      Consensus CDS
      CCDS41776.1
      UniProtKB/Swiss-Prot
      Q8WUI4
      Related
      ENSP00000351326.3, ENST00000354334.7
      Conserved Domains (1) summary
      cd10008
      Location:520897
      HDAC7; Histone deacetylase 7
    2. NM_001308090.2NP_001295019.1  histone deacetylase 7 isoform e

      See identical proteins and their annotated locations for NP_001295019.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter than isoform a.
      Source sequence(s)
      AK122588, AK299292, AK303481, BM144303, DC376749
      Consensus CDS
      CCDS81685.1
      UniProtKB/Swiss-Prot
      Q8WUI4
      Related
      ENSP00000448532.1, ENST00000552960.5
      Conserved Domains (1) summary
      cd10008
      Location:540917
      HDAC7; Histone deacetylase 7
    3. NM_001368046.1NP_001354975.1  histone deacetylase 7 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (f).
      Source sequence(s)
      AC004466
    4. NM_015401.5NP_056216.2  histone deacetylase 7 isoform a

      See identical proteins and their annotated locations for NP_056216.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as variant 3) encodes isoform a (also known as isoform c).
      Source sequence(s)
      AY302468, BC020505, DC376749
      Consensus CDS
      CCDS8756.2
      UniProtKB/Swiss-Prot
      Q8WUI4
      Related
      ENSP00000080059.7, ENST00000080059.12
      Conserved Domains (1) summary
      cd10008
      Location:557934
      HDAC7; Histone deacetylase 7

    RNA

    1. NR_160435.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004466
      Related
      ENST00000470668.5
    2. NR_160436.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004466

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      47782722..47821344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428980.1XP_047284936.1  histone deacetylase 7 isoform X6

    2. XM_047428979.1XP_047284935.1  histone deacetylase 7 isoform X5

    3. XM_011538481.2XP_011536783.2  histone deacetylase 7 isoform X1

    4. XM_047428983.1XP_047284939.1  histone deacetylase 7 isoform X9

    5. XM_047428978.1XP_047284934.1  histone deacetylase 7 isoform X2

    6. XM_024449018.2XP_024304786.1  histone deacetylase 7 isoform X3

      Conserved Domains (1) summary
      cd10008
      Location:564941
      HDAC7; Histone deacetylase 7
    7. XM_047428981.1XP_047284937.1  histone deacetylase 7 isoform X7

    8. XM_011538480.1XP_011536782.1  histone deacetylase 7 isoform X4

      Conserved Domains (1) summary
      cd10008
      Location:564941
      HDAC7; Histone deacetylase 7
    9. XM_047428982.1XP_047284938.1  histone deacetylase 7 isoform X8

      UniProtKB/Swiss-Prot
      Q9UFU7
      Related
      ENSP00000404394.2, ENST00000427332.6
    10. XM_047428984.1XP_047284940.1  histone deacetylase 7 isoform X8

      UniProtKB/Swiss-Prot
      Q9UFU7
    11. XM_011538483.1XP_011536785.1  histone deacetylase 7 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      47744115..47781298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016596.3: Suppressed sequence

      Description
      NM_016596.3: This RefSeq was temporarily suppressed because the CDS was partial.