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    CXXC5 CXXC finger protein 5 [ Homo sapiens (human) ]

    Gene ID: 51523, updated on 17-Jun-2019

    Summary

    Official Symbol
    CXXC5provided by HGNC
    Official Full Name
    CXXC finger protein 5provided by HGNC
    Primary source
    HGNC:HGNC:26943
    See related
    Ensembl:ENSG00000171604 MIM:612752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CF5; WID; RINF; HSPC195
    Summary
    The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See CXXC5 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139647299..139683885)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139028301..139063467)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 4 pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D2 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 236, pseudogene Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene PSD2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CXXC-type zinc finger protein 5
    Names
    CXXC finger 5 protein
    WT1-induced Inhibitor of Dishevelled
    putative MAPK-activating protein PM08
    putative NF-kappa-B-activating protein 102
    retinoid-inducible nuclear factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317199.2NP_001304128.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
      Source sequence(s)
      AK024338, BC006428, DA291558
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    2. NM_001317200.2NP_001304129.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AK001782, BC006428
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Related
      ENSP00000427379.1, ENST00000511048.1
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    3. NM_001317201.1NP_001304130.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BU187119, DA705695
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    4. NM_001317202.1NP_001304131.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BU187119, DA264868
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    5. NM_001317203.2NP_001304132.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC113361, BC006428, BI763590, DA031665
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    6. NM_001317204.2NP_001304133.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC113361, BC006428, DA031665
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    7. NM_001317205.1NP_001304134.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BU187119, DA170918
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    8. NM_001317206.1NP_001304135.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BU187119, CB140368, HY181287
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    9. NM_001317207.1NP_001304136.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BU187119, CB140368
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    10. NM_001317208.2NP_001304137.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, DB458723
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    11. NM_001317209.2NP_001304138.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY012710
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    12. NM_001317210.2NP_001304139.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY043636
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    13. NM_001317211.2NP_001304140.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY015270
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain
    14. NM_016463.9NP_057547.5  CXXC-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_057547.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AK024338, BC006428
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      Q7LFL8
      Related
      ENSP00000302543.3, ENST00000302517.8
      Conserved Domains (1) summary
      pfam02008
      Location:255296
      zf-CXXC; CXXC zinc finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      139647299..139683885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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