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    UFC1 ubiquitin-fold modifier conjugating enzyme 1 [ Homo sapiens (human) ]

    Gene ID: 51506, updated on 22-Jun-2019

    Summary

    Official Symbol
    UFC1provided by HGNC
    Official Full Name
    ubiquitin-fold modifier conjugating enzyme 1provided by HGNC
    Primary source
    HGNC:HGNC:26941
    See related
    Ensembl:ENSG00000143222 MIM:610554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDSG; HSPC155
    Summary
    UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 37.2), ovary (RPKM 36.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See UFC1 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161132703..161158856)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161123534..161128646)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 2 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene linc-UFC1 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene protoporphyrinogen oxidase Neighboring gene beta-1,4-galactosyltransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UFM1 transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K69-linked ufmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K69-linked ufmylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ufmylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ufmylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    ubiquitin-fold modifier-conjugating enzyme 1
    Names
    Ufm1-conjugating enzyme 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016406.4NP_057490.2  ubiquitin-fold modifier-conjugating enzyme 1

      See identical proteins and their annotated locations for NP_057490.2

      Status: VALIDATED

      Source sequence(s)
      AF151884
      Consensus CDS
      CCDS1220.1
      UniProtKB/Swiss-Prot
      Q9Y3C8
      Related
      ENSP00000356982.5, ENST00000368003.6
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      161132703..161158856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001450.2XP_016856939.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y3C8
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    2. XM_017001451.1XP_016856940.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y3C8
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    3. XM_005245254.1XP_005245311.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X2

      See identical proteins and their annotated locations for XP_005245311.1

      Conserved Domains (1) summary
      pfam08694
      Location:6110
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
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