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    REV1 REV1 DNA directed polymerase [ Homo sapiens (human) ]

    Gene ID: 51455, updated on 27-Nov-2024

    Summary

    Official Symbol
    REV1provided by HGNC
    Official Full Name
    REV1 DNA directed polymeraseprovided by HGNC
    Primary source
    HGNC:HGNC:14060
    See related
    Ensembl:ENSG00000135945 MIM:606134; AllianceGenome:HGNC:14060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REV1L; AIBP80
    Summary
    This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See REV1 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (99400477..99490202, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99859127..99948858, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (100016940..100106479, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99952564-99953104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99953733-99954234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99954235-99954734 Neighboring gene thioredoxin domain containing 9 Neighboring gene lysozyme g1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:100019841-100021040 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11809 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:100056357-100057026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:100092059-100092722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:100106417-100107302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100146131-100146758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100170377-100170925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100170926-100171473 Neighboring gene NANOG hESC enhancer GRCh37_chr2:100171857-100172363 Neighboring gene NANOG hESC enhancer GRCh37_chr2:100188674-100189175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100218069-100218631 Neighboring gene ALF transcription elongation factor 3 Neighboring gene uncharacterized LOC124906051 Neighboring gene uncharacterized LOC105373504

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21523, MGC26225, MGC163283

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables deoxycytidyl transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deoxycytidyl transferase activity TAS
    Traceable Author Statement
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in error-free translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in error-prone translesion synthesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DNA repair protein REV1
    Names
    REV1 homolog
    REV1, polymerase (DNA directed)
    REV1- like
    alpha integrin-binding protein 80
    rev1-like terminal deoxycytidyl transferase
    NP_001032961.1
    NP_001308383.1
    NP_001308384.1
    NP_001308387.1
    NP_001308388.1
    NP_001308389.1
    NP_057400.1
    XP_011509643.1
    XP_016859798.1
    XP_016859799.2
    XP_016859800.1
    XP_016859801.1
    XP_016859802.1
    XP_047300673.1
    XP_047300674.1
    XP_047300675.1
    XP_047300676.1
    XP_047300677.1
    XP_047300679.1
    XP_047300680.1
    XP_047300681.1
    XP_054198479.1
    XP_054198480.1
    XP_054198481.1
    XP_054198482.1
    XP_054198483.1
    XP_054198484.1
    XP_054198485.1
    XP_054198486.1
    XP_054198487.1
    XP_054198488.1
    XP_054198489.1
    XP_054198490.1
    XP_054198491.1
    XP_054198492.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037872.3NP_001032961.1  DNA repair protein REV1 isoform 2

      See identical proteins and their annotated locations for NP_001032961.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AB047646, BM683065, HY010913
      Consensus CDS
      CCDS42722.1
      UniProtKB/TrEMBL
      A1L461
      Related
      ENSP00000377091.3, ENST00000393445.7
      Conserved Domains (4) summary
      cd01701
      Location:348823
      PolY_Rev1; DNA polymerase Rev1
      smart00292
      Location:46118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9381056
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11291249
      REV1_C; DNA repair protein REV1 C-terminal domain
    2. NM_001321454.2NP_001308383.1  DNA repair protein REV1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AF206019, BM683065, DA304601
      UniProtKB/TrEMBL
      A1L461
      Conserved Domains (4) summary
      cd01701
      Location:348860
      PolY_Rev1; DNA polymerase Rev1
      smart00292
      Location:46118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9751093
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11661286
      REV1_C; DNA repair protein REV1 C-terminal domain
    3. NM_001321455.2NP_001308384.1  DNA repair protein REV1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AB047646, AC018690, BC037734, BM683065, HY010913
      UniProtKB/TrEMBL
      A1L461
      Conserved Domains (4) summary
      cd01701
      Location:278753
      PolY_Rev1; DNA polymerase Rev1
      smart00292
      Location:448
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:868986
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:10591179
      REV1_C; DNA repair protein REV1 C-terminal domain
    4. NM_001321458.2NP_001308387.1  DNA repair protein REV1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AB047646, AC018690, BM683065, DA304601, HY010913
      UniProtKB/Swiss-Prot
      Q9UBZ9
      Conserved Domains (3) summary
      cd01701
      Location:27334
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449567
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:640760
      REV1_C; DNA repair protein REV1 C-terminal domain
    5. NM_001321459.2NP_001308388.1  DNA repair protein REV1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) and variant 7 both encode the same isoform (6).
      Source sequence(s)
      AC018690, AF206019, BM683065, BP269179
      UniProtKB/Swiss-Prot
      Q9UBZ9
      Conserved Domains (3) summary
      cd01701
      Location:1301
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:416534
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:600727
      REV1_C; DNA repair protein REV1 C-terminal domain
    6. NM_001321460.2NP_001308389.1  DNA repair protein REV1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) and variant 6 both encode the same isoform (6).
      Source sequence(s)
      AB047646, AC018690, BM683065, BP269179, HY010913
      UniProtKB/Swiss-Prot
      Q9UBZ9
      Conserved Domains (3) summary
      cd01701
      Location:1301
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:416534
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:600727
      REV1_C; DNA repair protein REV1 C-terminal domain
    7. NM_016316.4NP_057400.1  DNA repair protein REV1 isoform 1

      See identical proteins and their annotated locations for NP_057400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC018690, AF151538, BM683065, HY010913
      Consensus CDS
      CCDS2045.1
      UniProtKB/Swiss-Prot
      O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
      UniProtKB/TrEMBL
      A1L461
      Related
      ENSP00000258428.3, ENST00000258428.8
      Conserved Domains (4) summary
      cd01701
      Location:348824
      PolY_Rev1; DNA polymerase Rev1
      smart00292
      Location:46118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9391057
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11301250
      REV1_C; DNA repair protein REV1 C-terminal domain

    RNA

    1. NR_135649.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018690, AK025176, BF934582, BM683065, BP269179, BP332286, CA951106, CK300059, CR736537, DA407212, DA852908, DR000409, HY010913
    2. NR_135650.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018690, BC037734, BM683065
      Related
      ENST00000413697.5
    3. NR_135651.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB047646, BM683065, HY010913
    4. NR_135652.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF206019, BC037734, BM683065
    5. NR_135653.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF206019, BM683065

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      99400477..99490202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004311.2XP_016859800.1  DNA repair protein REV1 isoform X6

      UniProtKB/TrEMBL
      A1L461
      Conserved Domains (4) summary
      cd01701
      Location:348860
      PolY_Rev1; DNA polymerase Rev1
      smart00292
      Location:46118
      BRCT; breast cancer carboxy-terminal domain
      pfam14377
      Location:9751093
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:11661286
      REV1_C; DNA repair protein REV1 C-terminal domain
    2. XM_047444723.1XP_047300679.1  DNA repair protein REV1 isoform X10

    3. XM_047444721.1XP_047300677.1  DNA repair protein REV1 isoform X9

      UniProtKB/Swiss-Prot
      O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
    4. XM_047444719.1XP_047300675.1  DNA repair protein REV1 isoform X7

    5. XM_017004312.3XP_016859801.1  DNA repair protein REV1 isoform X7

      UniProtKB/TrEMBL
      A1L461
      Conserved Domains (3) summary
      cd01701
      Location:348859
      PolY_Rev1; DNA polymerase Rev1
      cd12145
      Location:11921285
      Rev1_C; C-terminal domain of the Y-family polymerase Rev1
      cd17719
      Location:48131
      BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    6. XM_047444717.1XP_047300673.1  DNA repair protein REV1 isoform X2

    7. XM_017004309.3XP_016859798.1  DNA repair protein REV1 isoform X5

      UniProtKB/TrEMBL
      A1L461
    8. XM_017004310.2XP_016859799.2  DNA repair protein REV1 isoform X1

    9. XM_017004313.2XP_016859802.1  DNA repair protein REV1 isoform X4

      UniProtKB/TrEMBL
      A1L461
    10. XM_047444720.1XP_047300676.1  DNA repair protein REV1 isoform X8

    11. XM_047444718.1XP_047300674.1  DNA repair protein REV1 isoform X3

    12. XM_047444724.1XP_047300680.1  DNA repair protein REV1 isoform X11

    13. XM_011511341.3XP_011509643.1  DNA repair protein REV1 isoform X12

      See identical proteins and their annotated locations for XP_011509643.1

      Conserved Domains (3) summary
      cd01701
      Location:27334
      PolY_Rev1; DNA polymerase Rev1
      pfam14377
      Location:449567
      DUF4414; Domain of unknown function (DUF4414)
      pfam16727
      Location:640760
      REV1_C; DNA repair protein REV1 C-terminal domain
    14. XM_047444725.1XP_047300681.1  DNA repair protein REV1 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      99859127..99948858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342509.1XP_054198484.1  DNA repair protein REV1 isoform X6

    2. XM_054342514.1XP_054198489.1  DNA repair protein REV1 isoform X10

    3. XM_054342513.1XP_054198488.1  DNA repair protein REV1 isoform X9

      UniProtKB/Swiss-Prot
      O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
    4. XM_054342511.1XP_054198486.1  DNA repair protein REV1 isoform X7

    5. XM_054342510.1XP_054198485.1  DNA repair protein REV1 isoform X7

    6. XM_054342505.1XP_054198480.1  DNA repair protein REV1 isoform X2

    7. XM_054342508.1XP_054198483.1  DNA repair protein REV1 isoform X5

    8. XM_054342504.1XP_054198479.1  DNA repair protein REV1 isoform X1

    9. XM_054342507.1XP_054198482.1  DNA repair protein REV1 isoform X4

    10. XM_054342512.1XP_054198487.1  DNA repair protein REV1 isoform X8

    11. XM_054342506.1XP_054198481.1  DNA repair protein REV1 isoform X3

    12. XM_054342515.1XP_054198490.1  DNA repair protein REV1 isoform X11

    13. XM_054342516.1XP_054198491.1  DNA repair protein REV1 isoform X12

    14. XM_054342517.1XP_054198492.1  DNA repair protein REV1 isoform X13