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    CHST15 carbohydrate sulfotransferase 15 [ Homo sapiens (human) ]

    Gene ID: 51363, updated on 17-Jun-2019

    Summary

    Official Symbol
    CHST15provided by HGNC
    Official Full Name
    carbohydrate sulfotransferase 15provided by HGNC
    Primary source
    HGNC:HGNC:18137
    See related
    Ensembl:ENSG00000182022 MIM:608277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRAG; GALNAC4S-6ST
    Summary
    Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 9.9), spleen (RPKM 9.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See CHST15 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124006059..124093684, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125765669..125853200, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984128 Neighboring gene uncharacterized LOC107984276 Neighboring gene Y-box binding protein 2 pseudogene 1 Neighboring gene uncharacterized LOC105378536 Neighboring gene uncharacterized LOC107984184

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ60141, KIAA0598, MGC34346, DKFZp781H1369

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    chondroitin sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    hexose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    carbohydrate sulfotransferase 15
    Names
    B cell RAG associated protein (GALNAC4S-6ST)
    B-cell RAG-associated gene protein
    carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
    hBRAG
    NP_001257693.1
    NP_001257694.1
    NP_055678.2
    NP_056976.2
    XP_005269948.1
    XP_005269949.1
    XP_005269950.1
    XP_005269951.1
    XP_006717954.1
    XP_011538159.1
    XP_016871808.1
    XP_016871809.1
    XP_016871810.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032891.1 RefSeqGene

      Range
      5001..90942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270764.2NP_001257693.1  carbohydrate sulfotransferase 15 isoform 1

      See identical proteins and their annotated locations for NP_001257693.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF026477, BC027908, BC075813, CR749804
      Consensus CDS
      CCDS7638.1
      UniProtKB/Swiss-Prot
      Q7LFX5
      Related
      ENSP00000402394.1, ENST00000435907.6
      Conserved Domains (1) summary
      cl21551
      Location:253505
      Sulfotransfer_3; Sulfotransferase family
    2. NM_001270765.2NP_001257694.1  carbohydrate sulfotransferase 15 isoform 2

      See identical proteins and their annotated locations for NP_001257694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AL683842, BC050540, BM977716
      Consensus CDS
      CCDS55731.1
      UniProtKB/Swiss-Prot
      Q7LFX5
      Conserved Domains (1) summary
      cl21551
      Location:256407
      Sulfotransfer_3; Sulfotransferase family
    3. NM_014863.4NP_055678.2  carbohydrate sulfotransferase 15 isoform 2

      See identical proteins and their annotated locations for NP_055678.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AK294961, AL683842, BM977716
      Consensus CDS
      CCDS55731.1
      UniProtKB/TrEMBL
      B4DH74
      Related
      ENSP00000485905.1, ENST00000628426.1
      Conserved Domains (1) summary
      cl21551
      Location:256407
      Sulfotransfer_3; Sulfotransferase family
    4. NM_015892.5NP_056976.2  carbohydrate sulfotransferase 15 isoform 1

      See identical proteins and their annotated locations for NP_056976.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AF026477, BC027908, BC075813, BM193389
      Consensus CDS
      CCDS7638.1
      UniProtKB/Swiss-Prot
      Q7LFX5
      Related
      ENSP00000333947.6, ENST00000346248.7
      Conserved Domains (1) summary
      cl21551
      Location:253505
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      124006059..124093684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269894.5XP_005269951.1  carbohydrate sulfotransferase 15 isoform X4

      Conserved Domains (1) summary
      cl21551
      Location:253500
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_006717891.4XP_006717954.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_006717954.1

      UniProtKB/Swiss-Prot
      Q7LFX5
      Conserved Domains (1) summary
      cl21551
      Location:253505
      Sulfotransfer_3; Sulfotransferase family
    3. XM_017016319.1XP_016871808.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/Swiss-Prot
      Q7LFX5
      Conserved Domains (1) summary
      cl21551
      Location:253505
      Sulfotransfer_3; Sulfotransferase family
    4. XM_005269891.3XP_005269948.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_005269948.1

      UniProtKB/Swiss-Prot
      Q7LFX5
      Conserved Domains (1) summary
      cl21551
      Location:253505
      Sulfotransfer_3; Sulfotransferase family
    5. XM_005269892.4XP_005269949.1  carbohydrate sulfotransferase 15 isoform X2

      Conserved Domains (1) summary
      cl21551
      Location:253498
      Sulfotransfer_1; Sulfotransferase domain
    6. XM_017016320.1XP_016871809.1  carbohydrate sulfotransferase 15 isoform X2

      Conserved Domains (1) summary
      cl21551
      Location:253498
      Sulfotransfer_1; Sulfotransferase domain
    7. XM_005269893.3XP_005269950.1  carbohydrate sulfotransferase 15 isoform X3

      Conserved Domains (1) summary
      cl21551
      Location:253498
      Sulfotransfer_1; Sulfotransferase domain
    8. XM_017016321.1XP_016871810.1  carbohydrate sulfotransferase 15 isoform X3

      Conserved Domains (1) summary
      cl21551
      Location:253498
      Sulfotransfer_1; Sulfotransferase domain
    9. XM_011539857.1XP_011538159.1  carbohydrate sulfotransferase 15 isoform X5

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