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    RXFP3 relaxin family peptide receptor 3 [ Homo sapiens (human) ]

    Gene ID: 51289, updated on 17-Jun-2019


    Official Symbol
    RXFP3provided by HGNC
    Official Full Name
    relaxin family peptide receptor 3provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000182631 MIM:609445
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as

    Genomic context

    See RXFP3 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (33936386..33938918)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33936491..33939023)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 12 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 923, pseudogene Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene solute carrier family 45 member 2 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene alpha-methylacyl-CoA racemase

    Genomic regions, transcripts, and products


    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available fr...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Relaxin receptors, organism-specific biosystem (from REACTOME)
      Relaxin receptors, organism-specific biosystemRelaxins are part of a family of peptide hormones that diverged from insulin in early vertebrate evolution to form the insulin-like peptides and relaxins, now often referred to as the relaxin peptide...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Clone Names

    • MGC141998, MGC142000

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    galanin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    plasma membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    relaxin-3 receptor 1
    G-protein coupled receptor GPCR135
    G-protein coupled receptor SALPR
    RLN3 receptor 1
    g protein-coupled receptor SALPR
    relaxin/insulin like family peptide receptor 3
    somatostatin and angiotensin-like peptide receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016568.3NP_057652.1  relaxin-3 receptor 1

      See identical proteins and their annotated locations for NP_057652.1

      Status: VALIDATED

      Source sequence(s)
      AC139777, BC113438, D88437
      Consensus CDS
      ENSP00000328708.3, ENST00000330120.4
      Conserved Domains (1) summary
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1


    1. NT_187551.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      GenBank, FASTA, Sequence Viewer (Graphics)
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