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    SCAND1 SCAN domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 51282, updated on 11-Jun-2021

    Summary

    Official Symbol
    SCAND1provided by HGNC
    Official Full Name
    SCAN domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:10566
    See related
    Ensembl:ENSG00000171222 MIM:610416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAZ1; SDP1
    Summary
    This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 14.6), fat (RPKM 13.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SCAND1 in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35953624..35959472, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34541546..34547394, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene non-coding RNA activated by DNA damage Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene high mobility group box 3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    SCAN domain-containing protein 1
    Names
    SCAN-related protein RAZ1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385710.1NP_001372639.1  SCAN domain-containing protein 1

      Status: REVIEWED

      Source sequence(s)
      AL109965
      Related
      ENSP00000363103.3, ENST00000373991.3
      Conserved Domains (1) summary
      pfam02023
      Location:104162
      SCAN; SCAN domain
    2. NM_016558.4NP_057642.1  SCAN domain-containing protein 1

      See identical proteins and their annotated locations for NP_057642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AF207829, AL109965, BU848795
      Consensus CDS
      CCDS13269.1
      UniProtKB/Swiss-Prot
      P57086
      UniProtKB/TrEMBL
      Q9NZG6
      Related
      ENSP00000481289.1, ENST00000615116.1
      Conserved Domains (1) summary
      pfam02023
      Location:104162
      SCAN; SCAN domain
    3. NM_033630.3NP_361012.3  SCAN domain-containing protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an extra segment in the 5' coding region, compared to variant 1. These differences cause translation initiation at an upstream start codon, compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AL109965
      Related
      ENSP00000301995.2, ENST00000305978.7
      Conserved Domains (1) summary
      pfam02023
      Location:104162
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      35953624..35959472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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