Format

Send to:

Choose Destination
    • Showing Current items.

    IER5 immediate early response 5 [ Homo sapiens (human) ]

    Gene ID: 51278, updated on 15-Jun-2019

    Summary

    Official Symbol
    IER5provided by HGNC
    Official Full Name
    immediate early response 5provided by HGNC
    Primary source
    HGNC:HGNC:5393
    See related
    Ensembl:ENSG00000162783 MIM:607177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SBBI48
    Summary
    This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See IER5 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (181088502..181090843)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (181057638..181059979)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene syntaxin 6 Neighboring gene major histocompatibility complex, class I-related Neighboring gene VISTA enhancer hs1862 Neighboring gene long intergenic non-protein coding RNA 1732

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102760

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    immediate early response gene 5 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016545.5NP_057629.2  immediate early response gene 5 protein

      See identical proteins and their annotated locations for NP_057629.2

      Status: VALIDATED

      Source sequence(s)
      AA235294, AF178984, AI696140, AL356267
      Consensus CDS
      CCDS1343.1
      UniProtKB/Swiss-Prot
      Q5VY09
      Related
      ENSP00000356549.4, ENST00000367577.6
      Conserved Domains (1) summary
      pfam05760
      Location:1327
      IER; Immediate early response protein (IER)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      181088700..181092900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center