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    PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 51247, updated on 15-Jun-2019

    Summary

    Official Symbol
    PAIP2provided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17970
    See related
    Ensembl:ENSG00000120727 MIM:605604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAIP-2; PAIP2A
    Expression
    Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See PAIP2 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (139341832..139369720)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138677519..138705409)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene matrin 3 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene RN7SK pseudogene 64 Neighboring gene solute carrier family 23 member 1 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene proline rich basic protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC72018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation repressor activity, mRNA regulatory element binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 2
    Names
    PABC1-interacting protein 2
    PABP-interacting protein 2
    polyA-binding protein-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033112.2NP_001028284.1  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_001028284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BC062718, BU732743, DB448759
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      Q9BPZ3
      UniProtKB/TrEMBL
      Q49AE6
      Related
      ENSP00000422508.1, ENST00000510080.1
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. NM_016480.5NP_057564.3  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_057564.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BI552800, BU732743
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      Q9BPZ3
      UniProtKB/TrEMBL
      Q49AE6
      Related
      ENSP00000265192.4, ENST00000265192.9
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region

    RNA

    1. NR_109830.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC039337, BI552800, BU732743

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      139341832..139369720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009522.1XP_016865011.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9BPZ3
      Related
      ENSP00000378275.2, ENST00000394795.6
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. XM_017009523.2XP_016865012.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9BPZ3
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    3. XM_011543428.1XP_011541730.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011541730.1

      UniProtKB/Swiss-Prot
      Q9BPZ3
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
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