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    ELOA2 elongin A2 [ Homo sapiens (human) ]

    Gene ID: 51224, updated on 17-Jun-2019

    Summary

    Official Symbol
    ELOA2provided by HGNC
    Official Full Name
    elongin A2provided by HGNC
    Primary source
    HGNC:HGNC:30771
    See related
    Ensembl:ENSG00000206181 MIM:609522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT832; TCEB3B; TCEB3L
    Summary
    This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See ELOA2 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (47032572..47035617, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44558943..44561988, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene elongin A3 family member B Neighboring gene elongin A3 Neighboring gene uncharacterized LOC105372098 Neighboring gene haloacid dehalogenase like hydrolase domain containing 2 Neighboring gene small ubiquitin-related modifier 2 pseudogene

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC119351

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    elongin complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    elongin-A2
    Names
    RNA polymerase II transcription factor SIII subunit A2
    transcription elongation factor (SIII) elongin A2 elongin A2
    transcription elongation factor B polypeptide 3B
    transcription elongation factor B subunit 3B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050760.1 RefSeqGene

      Range
      5001..8046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016427.2NP_057511.2  elongin-A2

      See identical proteins and their annotated locations for NP_057511.2

      Status: REVIEWED

      Source sequence(s)
      AB030834, BC036022
      Consensus CDS
      CCDS11932.1
      UniProtKB/Swiss-Prot
      Q8IYF1
      Related
      ENSP00000331302.4, ENST00000332567.5
      Conserved Domains (2) summary
      smart00509
      Location:877
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam06881
      Location:544642
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      47032572..47035617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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