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    ZNF219 zinc finger protein 219 [ Homo sapiens (human) ]

    Gene ID: 51222, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZNF219provided by HGNC
    Official Full Name
    zinc finger protein 219provided by HGNC
    Primary source
    HGNC:HGNC:13011
    See related
    Ensembl:ENSG00000165804 MIM:605036; AllianceGenome:HGNC:13011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP219
    Summary
    This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF219 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21090077..21104722, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15287493..15302135, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21558236..21572881, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5579 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21539187-21539808 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:21550650-21551849 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21552808-21554007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21554944-21555488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21555489-21556031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21558438-21559283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21559284-21560128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5581 Neighboring gene Sharpr-MPRA regulatory region 8150 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21565235-21565736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21566496-21566996 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21571456-21572200 Neighboring gene transmembrane protein 253 Neighboring gene RNA, U6 small nuclear 252, pseudogene Neighboring gene cytoskeleton associated protein 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053108.1 RefSeqGene

      Range
      11068..19646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001101672.2NP_001095142.1  zinc finger protein 219

      See identical proteins and their annotated locations for NP_001095142.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK225811, BC000694
      Consensus CDS
      CCDS9568.1
      UniProtKB/Swiss-Prot
      D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
      UniProtKB/TrEMBL
      A8K3T5
      Related
      ENSP00000392401.2, ENST00000421093.6
      Conserved Domains (4) summary
      sd00017
      Location:500520
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:500520
      zf-C2H2; Zinc finger, C2H2 type
      pfam04959
      Location:304408
      ARS2; Arsenite-resistance protein 2
      pfam13465
      Location:512534
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001102454.2NP_001095924.1  zinc finger protein 219

      See identical proteins and their annotated locations for NP_001095924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK225811, AL161668, BC000694, DA013397
      Consensus CDS
      CCDS9568.1
      UniProtKB/Swiss-Prot
      D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
      UniProtKB/TrEMBL
      A8K3T5
      Related
      ENSP00000388558.2, ENST00000451119.6
      Conserved Domains (4) summary
      sd00017
      Location:500520
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:500520
      zf-C2H2; Zinc finger, C2H2 type
      pfam04959
      Location:304408
      ARS2; Arsenite-resistance protein 2
      pfam13465
      Location:512534
      zf-H2C2_2; Zinc-finger double domain
    3. NM_016423.3NP_057507.2  zinc finger protein 219

      See identical proteins and their annotated locations for NP_057507.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB015427, AL161668, BC000694, CB152705
      Consensus CDS
      CCDS9568.1
      UniProtKB/Swiss-Prot
      D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
      UniProtKB/TrEMBL
      A8K3T5
      Related
      ENSP00000354206.3, ENST00000360947.8
      Conserved Domains (4) summary
      sd00017
      Location:500520
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:500520
      zf-C2H2; Zinc finger, C2H2 type
      pfam04959
      Location:304408
      ARS2; Arsenite-resistance protein 2
      pfam13465
      Location:512534
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      21090077..21104722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      15287493..15302135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)