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    ZDHHC2 zinc finger DHHC-type containing 2 [ Homo sapiens (human) ]

    Gene ID: 51201, updated on 15-Jun-2019

    Summary

    Official Symbol
    ZDHHC2provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 2provided by HGNC
    Primary source
    HGNC:HGNC:18469
    See related
    Ensembl:ENSG00000104219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC2; ZNF372
    Expression
    Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See ZDHHC2 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (17156000..17230706)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17013836..17080241)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake family member 3 Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene CCR4-NOT transcription complex subunit 7 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene myotubularin related protein 7 Neighboring gene uncharacterized LOC102724838

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Surfactant metabolism, organism-specific biosystem (from REACTOME)
      Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
     
    protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC2
    Names
    DHHC-2
    ream
    rec
    reduced expression associated with metastasis protein
    reduced expression in cancer protein
    testis tissue sperm-binding protein Li 56e
    zinc finger DHHC domain-containing protein 2
    zinc finger protein 372
    zinc finger, DHHC domain containing 2
    NP_001349917.1
    NP_001349918.1
    NP_057437.1
    XP_011542846.1
    XP_011542847.1
    XP_011542848.1
    XP_011542850.1
    XP_011542851.1
    XP_024302945.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362988.1NP_001349917.1  palmitoyltransferase ZDHHC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC079193, AC091050
      Conserved Domains (1) summary
      pfam01529
      Location:99220
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_001362989.1NP_001349918.1  palmitoyltransferase ZDHHC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC079193, AC091050
      Conserved Domains (1) summary
      pfam01529
      Location:82203
      zf-DHHC; DHHC palmitoyltransferase
    3. NM_016353.5NP_057437.1  palmitoyltransferase ZDHHC2 isoform 1

      See identical proteins and their annotated locations for NP_057437.1

      Status: VALIDATED

      Source sequence(s)
      AB023584, AC091050
      Consensus CDS
      CCDS47810.1
      UniProtKB/Swiss-Prot
      Q9UIJ5
      UniProtKB/TrEMBL
      A0A140VKD9
      Related
      ENSP00000262096.8, ENST00000262096.13
      Conserved Domains (1) summary
      cl19890
      Location:13302
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      17156000..17230706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544549.3XP_011542851.1  palmitoyltransferase ZDHHC2 isoform X7

      Conserved Domains (1) summary
      cl19890
      Location:150203
      zf-DHHC; DHHC palmitoyltransferase
    2. XM_011544544.3XP_011542846.1  palmitoyltransferase ZDHHC2 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:172293
      zf-DHHC; DHHC palmitoyltransferase
    3. XM_011544545.3XP_011542847.1  palmitoyltransferase ZDHHC2 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:143264
      zf-DHHC; DHHC palmitoyltransferase
    4. XM_011544546.3XP_011542848.1  palmitoyltransferase ZDHHC2 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:128249
      zf-DHHC; DHHC palmitoyltransferase
    5. XM_024447177.1XP_024302945.1  palmitoyltransferase ZDHHC2 isoform X5

      Conserved Domains (1) summary
      pfam01529
      Location:82203
      zf-DHHC; DHHC palmitoyltransferase
    6. XM_011544548.3XP_011542850.1  palmitoyltransferase ZDHHC2 isoform X6

      See identical proteins and their annotated locations for XP_011542850.1

      Conserved Domains (1) summary
      pfam01529
      Location:71192
      zf-DHHC; DHHC palmitoyltransferase
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