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    IPO11 importin 11 [ Homo sapiens (human) ]

    Gene ID: 51194, updated on 17-Jun-2024

    Summary

    Official Symbol
    IPO11provided by HGNC
    Official Full Name
    importin 11provided by HGNC
    Primary source
    HGNC:HGNC:20628
    See related
    Ensembl:ENSG00000086200 MIM:610889; AllianceGenome:HGNC:20628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RanBP11
    Summary
    Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IPO11 in Genome Data Viewer
    Location:
    5q12.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62412763..62628582)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63232336..63448295)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61708590..61924409)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22596 Neighboring gene kinesin family member 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16052 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61791875-61792070 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61864515-61865147 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61865148-61865779 Neighboring gene IPO11-LRRC70 readthrough Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61905853-61905971 Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene leucine rich repeat containing 70 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:62013981-62014721 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:62265821-62266321 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62277957-62278458 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62278459-62278958 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:62421058-62421608 Neighboring gene MPRA-validated peak5264 silencer Neighboring gene dedicator of cytokinesis 9 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough IPO11-LRRC70

    Readthrough gene: IPO11-LRRC70, Included gene: LRRC70

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    importin-11
    Names
    Ran binding protein 11
    imp11
    ran-binding protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134779.2NP_001128251.1  importin-11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF111109, AK302781, BC033776, BM966917
      Consensus CDS
      CCDS47217.1
      UniProtKB/TrEMBL
      F8WDV0
      Related
      ENSP00000386992.3, ENST00000409296.7
      Conserved Domains (3) summary
      COG5657
      Location:501012
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam03810
      Location:68140
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:466499
      HEAT; HEAT repeat [structural motif]
    2. NM_016338.5NP_057422.3  importin-11 isoform 2

      See identical proteins and their annotated locations for NP_057422.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AF111109, BC033776, BM966917, DA473424
      Consensus CDS
      CCDS34167.1
      UniProtKB/Swiss-Prot
      A6NGJ5, B4DZ73, D3DW98, Q8N5R2, Q9NSJ6, Q9NVB1, Q9UI26
      UniProtKB/TrEMBL
      F8WDV0
      Related
      ENSP00000316651.6, ENST00000325324.11
      Conserved Domains (2) summary
      sd00044
      Location:426459
      HEAT; HEAT repeat [structural motif]
      cl27876
      Location:10972
      Cse1; Cse1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      62412763..62628582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      63232336..63448295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)