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    ADIPOR1 adiponectin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 51094, updated on 12-Sep-2021

    Summary

    Official Symbol
    ADIPOR1provided by HGNC
    Official Full Name
    adiponectin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:24040
    See related
    Ensembl:ENSG00000159346 MIM:607945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
    Summary
    This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ADIPOR1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (202940825..202958572, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202909953..202927700, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB interacting factor Neighboring gene kelch like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene Sharpr-MPRA regulatory region 11793 Neighboring gene cytochrome b5 reductase 1 Neighboring gene MGAT4 family member F, pseudogene Neighboring gene ribosomal protein S20 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25385, FLJ42464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adiponectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adiponectin receptor protein 1
    Names
    progestin and adipoQ receptor family member 1
    progestin and adipoQ receptor family member I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052860.1 RefSeqGene

      Range
      5001..22748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290553.2NP_001277482.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AI251444, BC010743, DA523648
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      Q96A54
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related
    2. NM_001290557.1NP_001277486.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277486.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC096632, AI251444, BC010743, BI597715
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      Q96A54
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related
    3. NM_001290629.1NP_001277558.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001277558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AI251444, BC010743, BI597715, BX461217
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      Q96A54
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related
    4. NM_015999.6NP_057083.2  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_057083.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.
      Source sequence(s)
      AC096632, AI251444, BC010743
      Consensus CDS
      CCDS1430.1
      UniProtKB/Swiss-Prot
      Q96A54
      Related
      ENSP00000341785.5, ENST00000340990.10
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      202940825..202958572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447427.1XP_024303195.1  adiponectin receptor protein 1 isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:11197
      HlyIII; Haemolysin-III related
    2. XM_017001407.1XP_016856896.1  adiponectin receptor protein 1 isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:11197
      HlyIII; Haemolysin-III related

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_046083.1: Suppressed sequence

      Description
      NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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