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    PLLP plasmolipin [ Homo sapiens (human) ]

    Gene ID: 51090, updated on 18-Sep-2024

    Summary

    Official Symbol
    PLLPprovided by HGNC
    Official Full Name
    plasmolipinprovided by HGNC
    Primary source
    HGNC:HGNC:18553
    See related
    Ensembl:ENSG00000102934 MIM:600340; AllianceGenome:HGNC:18553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PMLP; TM4SF11
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in compact myelin and membrane raft. Predicted to be integral component of membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 41.3), stomach (RPKM 28.7) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PLLP in Genome Data Viewer
    Location:
    16q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57256097..57284672, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63052086..63080643, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57290009..57318584, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7524 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:57220937-57221581 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7526 Neighboring gene uncharacterized LOC124903697 Neighboring gene ARF like GTPase 2 binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57292150-57292362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57292975-57293530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57295195-57295750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57295751-57296304 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:57296526-57297296 and GRCh37_chr16:57297297-57298066 Neighboring gene Sharpr-MPRA regulatory region 12895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57317662-57318323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7527 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57321027-57321239 Neighboring gene Sharpr-MPRA regulatory region 5344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7529 Neighboring gene tRNA-Leu (anticodon CAG) 2-1 Neighboring gene tRNA-Leu (anticodon CAG) 2-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in compact myelin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    plasmolipin
    Names
    plasma membrane proteolipid (plasmolipin)
    transmembrane 4 superfamily member 11 (plasmolipin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015993.3NP_057077.1  plasmolipin

      See identical proteins and their annotated locations for NP_057077.1

      Status: VALIDATED

      Source sequence(s)
      BC002760, DA366260
      Consensus CDS
      CCDS10777.1
      UniProtKB/Swiss-Prot
      B2R9T6, Q9Y342
      UniProtKB/TrEMBL
      A8K0N4
      Related
      ENSP00000219207.5, ENST00000219207.10
      Conserved Domains (1) summary
      pfam01284
      Location:32160
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57256097..57284672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63052086..63080643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)