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    MED31 mediator complex subunit 31 [ Homo sapiens (human) ]

    Gene ID: 51003, updated on 17-Jun-2024

    Summary

    Official Symbol
    MED31provided by HGNC
    Official Full Name
    mediator complex subunit 31provided by HGNC
    Primary source
    HGNC:HGNC:24260
    See related
    Ensembl:ENSG00000108590 MIM:620492; AllianceGenome:HGNC:24260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Soh1; SEP10; CGI-125; 3110004H13Rik
    Summary
    Predicted to enable transcription coregulator activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 6.0), adrenal (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MED31 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6643311..6651605, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6543942..6552234, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6546631..6554925, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KIAA0753 Neighboring gene RNA, 5S ribosomal pseudogene 435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540081-6540863 Neighboring gene uncharacterized LOC122526780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540864-6541645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11584 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6543558-6544439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11586 Neighboring gene thioredoxin domain containing 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6558426-6558998 Neighboring gene chromosome 17 open reading frame 100 Neighboring gene microRNA 4520-1 Neighboring gene microRNA 4520-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of mediator complex subunit 31 (MED31) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of MED31 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ27436, FLJ36714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 31
    Names
    hSOH1
    mediator complex subunit SOH1
    mediator of RNA polymerase II transcription, subunit 31 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016060.3NP_057144.1  mediator of RNA polymerase II transcription subunit 31

      See identical proteins and their annotated locations for NP_057144.1

      Status: VALIDATED

      Source sequence(s)
      AC004706, AF151883
      Consensus CDS
      CCDS11078.1
      UniProtKB/Swiss-Prot
      B2R4L9, Q9Y3C7
      Related
      ENSP00000225728.3, ENST00000225728.8
      Conserved Domains (1) summary
      pfam05669
      Location:15108
      Med31; SOH1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      6643311..6651605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      6543942..6552234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)