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    ATP5F1C ATP synthase F1 subunit gamma [ Homo sapiens (human) ]

    Gene ID: 509, updated on 17-Jun-2019

    Summary

    Official Symbol
    ATP5F1Cprovided by HGNC
    Official Full Name
    ATP synthase F1 subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:833
    See related
    Ensembl:ENSG00000165629 MIM:108729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATP5C; ATP5C1; ATP5CL1
    Summary
    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 224.0), adrenal (RPKM 140.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See ATP5F1C in Genome Data Viewer
    Location:
    10p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (7788104..7807801)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7830093..7849764)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC105376394

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    capsid gag The interaction of HIV-1 CA with human cellular ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    ATP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ATP biosynthetic process TAS
    Traceable Author Statement
    more info
     
    ATP synthesis coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cristae formation TAS
    Traceable Author Statement
    more info
     
    mitochondrial ATP synthesis coupled proton transport IC
    Inferred by Curator
    more info
    PubMed 
    mitochondrial ATP synthesis coupled proton transport TAS
    Traceable Author Statement
    more info
     
    oxidative phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane HDA PubMed 
    mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrial proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP synthase subunit gamma, mitochondrial
    Names
    ATP synthase gamma chain, mitochondrial
    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
    F-ATPase gamma subunit
    mitochondrial ATP synthase, gamma subunit 1
    NP_001001973.1
    NP_001307815.1
    NP_005165.1
    XP_016871779.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001973.3NP_001001973.1  ATP synthase subunit gamma, mitochondrial isoform L (liver) precursor

      See identical proteins and their annotated locations for NP_001001973.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (L), also known as a liver type isoform.
      Source sequence(s)
      BC026049, BQ893894, D16562
      Consensus CDS
      CCDS31142.1
      UniProtKB/Swiss-Prot
      P36542
      UniProtKB/TrEMBL
      Q8TAS0
      Related
      ENSP00000349142.7, ENST00000356708.12
      Conserved Domains (1) summary
      TIGR01146
      Location:26297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    2. NM_001320886.1NP_001307815.1  ATP synthase subunit gamma, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3, which lacks a mitochondrial transit peptide compared to isoforms L and H.
      Source sequence(s)
      BC026049, BE161935, BI603806, CB144767
      UniProtKB/TrEMBL
      Q8TAS0
      Conserved Domains (1) summary
      TIGR01146
      Location:1250
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    3. NM_005174.3NP_005165.1  ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor

      See identical proteins and their annotated locations for NP_005165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the coding region compared to variant 1. The resulting isoform (H), also known as a heart type isoform, contains a shorter and distinct C-terminus compared to isoform L.
      Source sequence(s)
      BC026049, BE161935, BQ893894, CB144767, D16563
      Consensus CDS
      CCDS7081.1
      UniProtKB/Swiss-Prot
      P36542
      UniProtKB/TrEMBL
      Q8TAS0
      Related
      ENSP00000338568.4, ENST00000335698.4
      Conserved Domains (1) summary
      TIGR01146
      Location:26297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      7788104..7807801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016290.1XP_016871779.1  ATP synthase subunit gamma, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B4DL14
      Conserved Domains (1) summary
      TIGR01146
      Location:1250
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
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