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    Mapk3 mitogen activated protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50689, updated on 23-Apr-2019

    Summary

    Official Symbol
    Mapk3provided by RGD
    Official Full Name
    mitogen activated protein kinase 3provided by RGD
    Primary source
    RGD:3046
    See related
    Ensembl:ENSRNOG00000053583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk
    Summary
    kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Lung (RPKM 210.4), Brain (RPKM 104.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Mapk3 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198192773..198198975)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (205172641..205178843)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349782 Neighboring gene uncharacterized LOC102551806 Neighboring gene 60S ribosomal protein L18-like Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene yippee-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Bergmann glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Bergmann glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA damage induced protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiac neural crest cell development involved in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac neural crest cell development involved in heart development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    caveolin-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to dopamine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to dopamine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    decidualization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    face development IEA
    Inferred from Electronic Annotation
    more info
     
    face development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apolipoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    outer ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    outer ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytokine secretion involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of histone phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomere capping IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of xenophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of xenophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of Golgi inheritance TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cellular pH IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular pH ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of early endosome to late endosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    response to epidermal growth factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to epidermal growth factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    trachea formation IEA
    Inferred from Electronic Annotation
    more info
     
    trachea formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    late endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pseudopodium IEA
    Inferred from Electronic Annotation
    more info
     
    pseudopodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 3
    Names
    MAP kinase 1
    MAP kinase 3
    MAP kinase isoform p44
    MAPK 1
    MAPK 3
    extracellular signal-regulated kinase 1
    insulin-stimulated MAP2 kinase
    microtubule-associated protein 2 kinase
    mitogen-activated 3
    mitogen-activated protein kinase 1
    NP_059043.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017347.2NP_059043.1  mitogen-activated protein kinase 3

      See identical proteins and their annotated locations for NP_059043.1

      Status: PROVISIONAL

      Source sequence(s)
      S46779
      UniProtKB/Swiss-Prot
      P21708
      Related
      ENSRNOP00000070784.1, ENSRNOT00000087625.1
      Conserved Domains (2) summary
      smart00220
      Location:43331
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07849
      Location:37371
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      198192773..198198975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      179022318..179028386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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