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    ATP5F1B ATP synthase F1 subunit beta [ Homo sapiens (human) ]

    Gene ID: 506, updated on 7-Jul-2019

    Summary

    Official Symbol
    ATP5F1Bprovided by HGNC
    Official Full Name
    ATP synthase F1 subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:830
    See related
    Ensembl:ENSG00000110955 MIM:102910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATP5B; ATPMB; ATPSB; HEL-S-271
    Summary
    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See ATP5F1B in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56638175..56645984, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57031959..57039852, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene Sharpr-MPRA regulatory region 9353 Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene RNA, 7SL, cytoplasmic 809, pseudogene Neighboring gene prostaglandin E synthase 3 Neighboring gene nascent polypeptide associated complex subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) in Jurkat cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase beta subunit (ATP5B) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the ATP5F1B gene: The ATP5F1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 240 organisms have orthologs with human gene ATP5F1B

    Clone Names

    • MGC5231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiostatin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proton-transporting ATP synthase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proton-transporting ATPase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transporter activity IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP synthase subunit beta, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
    epididymis secretory protein Li 271
    mitochondrial ATP synthase beta subunit
    mitochondrial ATP synthetase, beta subunit
    NP_001677.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001686.4NP_001677.2  ATP synthase subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001677.2

      Status: REVIEWED

      Source sequence(s)
      BC016512, BI561028
      Consensus CDS
      CCDS8924.1
      UniProtKB/Swiss-Prot
      P06576
      UniProtKB/TrEMBL
      V9HW31
      Related
      ENSP00000262030.3, ENST00000262030.8
      Conserved Domains (1) summary
      PRK09280
      Location:58524
      PRK09280; F0F1 ATP synthase subunit beta; Validated

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      56638175..56645984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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